Key takeaways:
Tezspire (tezepelumab) is a biologic injection that helps treat severe asthma and chronic rhinosinusitis with nasal polyps (inflamed nasal passages). It can cost over $4,000 per dose without insurance.
What you pay for Tezspire may depend on factors such as your insurance coverage, the dosage form you’re prescribed, and where you live.
A manufacturer copay savings card or patient assistance program may help lower your out-of-pocket costs for Tezspire. Talk with your prescriber, specialty pharmacy team, or insurance provider for guidance.
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Tezspire (tezepelumab) is a biologic injection that helps treat severe asthma and chronic rhinosinusitis with nasal polyps (inflamed nasal passages). It's given once every 4 weeks to help reduce inflammation and other symptoms.
Because Tezspire is a biologic medication, it can cost more than other, traditional asthma medications. Let’s review how much Tezspire costs without insurance, along with ways to help make it more affordable.
How much does Tezspire cost without insurance?
The manufacturer’s list price for Tezspire is about $4,587 per dose for the prefilled syringe and $4,909 per dose for the injection. But like the retail price, which is slightly different because it’s affected by pharmacy and wholesaler markups, this isn’t what most people actually pay.
If you have prescription medication coverage or qualify for savings programs, what you pay out-of-pocket may be much lower than both the list and average retail price.
What factors affect the cost of Tezspire?
Several factors can affect how much you pay for Tezspire. Here are some notable ones to keep in mind.
Biosimilar availability
As mentioned, Tezspire is a biologic medication. Biologics don’t have traditional generics. Instead, a biologic can have biosimilars, which are highly similar (but not identical) to the original (reference) medication.
Tezspire is currently only available as a reference (“brand-name”) product. This can play a role in its high price, since a biosimilar could help you access the medication at a lower cost.
Dosage form
Tezspire comes in three different dosage forms:
A single-dose prefilled syringe
A single-dose injection pen
A single-dose vial
The cost of Tezspire may depend on what dosage form you’re prescribed. For example, the injection pen tends to cost more than the other forms. But it’s the only form you can inject on your own at home.
Both the vial and prefiled syringe are injected by a healthcare professional. So there may be extra costs beyond the medication itself, such as administration fees.
Location
Medication prices often vary by geographic location. Different states, cities, and regions may have different pricing for the same treatments. For instance, prices for prescription medications are generally lower in Tampa, Florida, than in New York City.
Pharmacy
Tezspire is considered a specialty medication. This means you’ll likely need to get it from a specialty pharmacy. Different specialty pharmacies may offer different pricing and savings opportunities. But your insurance plan may prefer a specific location. Researching your options in advance can help you find the best price.
Insurance coverage
Whether you have insurance plays a big role in your out-of-pocket costs. If you do, your plan may cover Tezspire outright. But some plans may require prior authorization or step therapy. A prior authorization requirement means your prescriber will need to provide information to your insurer before they’ll cover the medication. Doing step therapy requires you to try one or more lower-cost treatments before moving to Tezspire.
Your out-of-pocket costs also depend on your plan's coverage rules. Factors that can affect what you pay include:
Where Tezspire is placed within your plan’s formulary (list of covered medications)
Your deductible
Checking your insurance plan's formulary and looking into coverage requirements in advance can help you estimate your costs before starting treatment. You can usually access this information online or by calling the customer service number on the back of your prescription insurance card.
Good to know: Tezspire may be covered under your medical insurance instead of your prescription insurance if you’re receiving it in a medical office rather than injecting it yourself at home. In this case, your prescriber’s office can help you navigate the expected treatment costs.
What to do if Tezspire isn’t covered by your insurance
If your insurance doesn’t cover Tezspire, consider these options:
Request a formulary exception from your insurance company.
File an appeal if coverage is denied.
Talk to your prescriber about potential Tezspire alternatives, such as Xolair (omalizumab), to see if there’s an option that’s covered by your insurance plan.
During your next open enrollment window, look for a health insurance plan that includes Tezspire as a covered medication.
Ways to save on Tezspire
There are several ways to potentially lower your out-of-pocket costs for Tezspire. Here are four to consider.
1. See if you qualify for a copay savings card
The Tezspire Together Co-Pay Program may help you pay as little as $0 per dose if you have commercial insurance coverage. It can also take up to $100 per month off any administration costs for in-office injections (except if you live in Massachusetts or Rhode Island).
To qualify for this program, you must:
Have commercial insurance coverage
Not have government-funded insurance, such as Medicare or Medicaid
Live in the U.S., Puerto Rico, or another U.S. territory
You can enroll in the program online or call 1-800-818-1770 for more information.
2. Check if you’re eligible for the manufacturer’s patient assistance program
If you're uninsured or underinsured, you may qualify for the Tezspire Together patient assistance program, which offers the medication at no cost to eligible applicants.
To qualify, you must:
Be uninsured or have government-funded insurance with a copay of more than $100 for Tezspire
Be a resident of the U.S., Puerto Rico, or another U.S. territory for at least 6 months
Have a household income at or below 500% of the federal poverty level
Your prescriber will need to enroll you in this program. But you can call 1-888-897-7473 to get more information and determine your eligibility.
3. Look into independent patient assistance programs
Several nonprofit organizations also offer patient assistance programs that could help lower your costs. These are often catered to people living with a specific health condition, and each program has its own eligibility criteria. Examples of organizations that offer these programs include:
Keep in mind that you may need to join a wait list if a program isn’t currently accepting new applicants.
4. Tap into your HSA, FSA, or HRA
If you have a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA), you can use it to help cover your out-of-pocket costs for Tezspire. These tax-advantaged healthcare accounts let you pay for eligible expenses with tax-free dollars.
Pay directly with your HSA or FSA card at the pharmacy, or cover the cost yourself and submit a request for reimbursement. The funds in HSAs roll over annually. But you typically have to use FSA dollars before a certain deadline or they’ll expire.
The bottom line
Tezspire (tezepelumab) is a biologic injection used to help treat severe asthma and chronic rhinosinusitis with nasal polyps. Without insurance or discounts, Tezspire could cost over $4,000 per dose. The amount you’ll pay may vary based on the dosage form you’re prescribed, where you live, and whether or not you have insurance coverage. Additional administration costs may also apply if you receive Tezspire in a medical setting rather than injecting it at home.
If you need help paying for Tezspire, several resources are available. A manufacturer copay savings card, patient assistance programs, and tax-advantaged healthcare funds can all help lower your out-of-pocket costs. Talking with your prescriber, specialty pharmacy team, or insurance provider can help you find the best option for your situation.
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References
Amgen. (2025). Tezspire - tezepelumab-ekko injection, solution [package insert].
HealthWell Foundation. (n.d.). Disease funds.
Patient Access Network Foundation. (n.d.). Asthma.
Tezspire. (n.d.). Your guide to Tezspire pricing and support. AstraZeneca.
Tezspire. (2024). For eligible patients: How to use the Tezspire Together Co-Pay Program. AstraZeneca.
Tezspire Together. (2025). Pre-screen your patients for the patient assistance program (PAP) with Tezspire Together. Amgen.
The Assistance Fund. (n.d.). Asthma copay assistance program.


