Prochlorperazine (Compro) rectal suppository is a typical antipsychotic. It's FDA-approved to treat severe nausea and vomiting in adults. But prochlorperazine (Compro) isn't a first-choice antiemetic because it can cause serious side effects, such as extreme sleepiness and uncontrolled muscle movements. While prochlorperazine (Compro) is a good option for people who can't take medications by mouth, some people might find it unpleasant or difficult to use because it needs to be inserted into the rectum, typically twice daily. Prochlorperazine (Compro) comes as a brand-name and generic medication.
Prochlorperazine (Compro) is an anti-nausea (antiemetic) medication that's classified as a typical antipsychotic based on how it works in the body. Prochlorperazine (Compro) mainly works by blocking dopamine, a chemical made by your brain that affects many parts of the body. When prochlorperazine (Compro) blocks dopamine in the brain, it eases nausea and vomiting.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Phenothiazines can sometimes cause serious unwanted effects. Tardive dyskinesia or tardive dystonia (muscle movement disorders) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia or tardive dystonia include worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, body, arms, or legs. Another possible serious unwanted effect is the neuroleptic malignant syndrome (NMS). Signs and symptoms of NMS include severe muscle stiffness, fever, fast heartbeat, difficult breathing, increased sweating, and loss of bladder control. You and your doctor should discuss the good this medicine will do as well as the risks of taking it.
Stop taking this medicine and get emergency help immediately if any of the following effects occur:
Rare
Symptoms of neuroleptic malignant syndrome
Confusion (severe) or coma
difficult or fast breathing
fast heartbeat
high or low (irregular) blood pressure
increased sweating
loss of bladder control
muscle stiffness (severe)
trembling or shaking
trouble in speaking or swallowing
Check with your doctor immediately if any of the following side effects occur:
More common
Inability to move eyes
increased blinking or spasms of eyelid
lip smacking or puckering
muscle spasms of face, neck, body, arms, or legs causing unusual postures or unusual expressions on face
puffing of cheeks
rapid or worm-like movements of tongue
sticking out of tongue
tic-like or twitching movements
trouble in breathing, speaking, or swallowing
uncontrolled chewing movements
uncontrolled movements of arms or legs
uncontrolled twisting movements of neck, trunk, arms, or leg
Rare
Irregular or slow heart rate
recurrent fainting
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Blurred vision, change in color vision, or difficulty in seeing at night
fainting
loss of balance control
mask-like face
restlessness or need to keep moving
shuffling walk
stiffness of arms or legs
trembling and shaking of hands and fingers
Less common
Difficulty in urinating
skin rash
sunburn (severe)
Rare
Abdominal or stomach pains
aching muscles and joints
agitation, bizarre dreams, excitement, or trouble in sleeping
bleeding or bruising (unusual
clumsiness
confusion (mild)
constipation (severe)
convulsions (seizures)
dark urine
fever and chills
headaches
hot, dry skin or lack of sweating
itchy skin (severe)
muscle weakness
pain in joints
prolonged, painful, inappropriate erection of the penis
redness of hands
shivering
skin discoloration (tan or blue-gray)
sore throat and fever
sores in mouth
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Phenothiazines may cause your urine to be dark. In most cases, this is not a sign of a serious problem. However, if your urine does become dark, discuss it with your doctor.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Changes in menstrual period
decreased sexual ability
increased sensitivity of eyes to light
rough or “fuzzy” tongue
secretion of milk (unusual)
swelling or pain in breasts
watering of mouth
weight gain (unusual)
After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this time, check with your doctor if you notice dizziness, nausea and vomiting, stomach pain, trembling of the fingers and hands, or any of the following signs of tardive dyskinesia or tardive dystonia:
Inability to move eyes
lip smacking or puckering
muscle spasms of face, neck, body, arms, or legs, causing unusual body positions or unusual expressions on face
puffing of cheeks
rapid or worm-like movements of tongue
sticking out of tongue
tic-like or twitching movements
trouble in breathing, speaking, or swallowing
uncontrolled chewing movements
uncontrolled twisting or other movements of neck, trunk, arms, or legs
Although not all of the side effects listed above have been reported for all of the phenothiazines, they have been reported for at least one of them. However, since all of the phenothiazines are very similar, any of the above side effects may occur with any of these medicines.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
No, prochlorperazine (Compro) isn't a controlled substance. It isn't known to cause physical and mental dependence.
Prochlorperazine (Compro) rectal suppository typically starts to relieve nausea or vomiting about an hour after a dose.
There's not enough research to know how long prochlorperazine (Compro) rectal suppository stays in your system after a dose. But based on studies of prochlorperazine oral tablets, it takes about 1-2 days for most of this medication to leave your system after a single oral dose. This time frame is estimated based on the half-life of prochlorperazine oral tablets. It's unclear whether it'll take a similar amount of time for most of prochlorperazine (Compro) rectal suppository to leave your system after a dose. Talk with your healthcare team if you have questions about how long prochlorperazine (Compro) stays in your body.
Yes, drowsiness is one of the more common side effects of prochlorperazine (Compro). You're more likely to experience this side effect when you first start taking this medication. So it's important to avoid driving or doing other activities that need a lot of focus until you know how this medication makes you feel. If you continue to feel sleepy from taking prochlorperazine (Compro), talk with your healthcare team. They can try to ease this side effect by adjusting your dose or the time(s) that you take your medication, or they can talk with you about other options to treat nausea and vomiting.
Constipation isn't a common side effect of prochlorperazine (Compro) rectal suppository. But there's a chance that you can experience constipation from this medication. That's because based on how prochlorperazine (Compro) works, it can act like an anticholinergic medication. And constipation is a side effect of anticholinergic medications. Talk with your healthcare team if you're concerned about constipation. They can recommend ways to prevent or ease constipation, such as by drinking more water to stay hydrated and by adding more fiber to your diet through eating foods such as vegetables, whole grains, and nuts.
People typically don't report anxiety as a side effect from prochlorperazine (Compro) suppository. In fact, oral prochlorperazine tablet is FDA-approved to treat generalized anxiety disorder (GAD) short-term, though it's not a first-choice medication for this condition. If you notice you're feeling more anxious after starting prochlorperazine (Compro), talk with your healthcare team. They can help you figure out what might be causing those symptoms.
How long the side effects of prochlorperazine (Compro) last can differ depending on what symptoms you're experiencing. For example, you're more likely to experience dizziness when you first start this medication, but this side effect can ease over time. But prochlorperazine (Compro) can also cause rare side effects, like uncontrolled muscle movements, that can last as long as you're taking this medication. Rarely, prochlorperazine (Compro) can cause a serious movement-related side effect called tardive dyskinesia that can be permanent. Talk with your healthcare team if you have questions about any particular side effect.
Prochlorperazine (Compro) isn't recommended for morning sickness because it hasn't been well-studied during pregnancy. Babies born to mothers who took similar medications during the 3rd trimester of pregnancy have developed uncontrolled muscle movement or withdrawal symptoms at birth, such as vomiting, diarrhea, and difficulty sleeping. Your obstetrician-gynecologist (OB-GYN) might consider prochlorperazine (Compro) as a possible option for your morning sickness if it's severe and no other medications worked, and if the benefits of trying prochlorperazine (Compro) outweigh the risks of harm.
Prochlorperazine (Compro) suppository and prochlorperazine oral tablet contain the same active medication. But there are some differences between them. One difference is what they're FDA-approved to treat. Both prochlorperazine (Compro) suppository and oral tablet are FDA-approved to control nausea and vomiting. But prochlorperazine oral tablet can also be prescribed for schizophrenia and generalized anxiety disorder (GAD). Another difference is how you take the medications. The tablet is taken by mouth, typically 3 to 4 times a day. But the suppository is inserted into the rectum, usually twice a day. The suppository is a possible option for people who have a hard time swallowing tablets, but some people might find it unpleasant or difficult to use. Talk to your healthcare team to see what form of prochlorperazine is best for you.
Prochlorperazine (Compro) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
People over the age of 65 who also have dementia sometimes have some of the symptoms of schizophrenia, like hallucinations and delusions. This is called dementia-related psychosis, and it should not be treated with prochlorperazine (Compro). If prochlorperazine (Compro) is used for dementia-related psychosis, it can cause death. Let your healthcare team know if you or your loved one has dementia before starting prochlorperazine (Compro).
Prochlorperazine (Compro) can cause uncontrolled and possibly permanent muscle movements in the tongue, face, mouth, lips, neck, hands, arms, legs, and feet (tardive dyskinesia). To lower your risk of tardive dyskinesia, take the lowest dose possible for the shortest period of time for your symptoms. Stop taking prochlorperazine (Compro) and talk to your healthcare team right away if you notice any unusual movements you can't control.
Prochlorperazine (Compro) can cause other uncontrolled muscle movements in addition to tardive dyskinesia, such as repeated stiffening and twisting of muscles, tremors, jitteriness, pacing, and foot tapping. Symptoms might occur as early as within the first few days of taking prochlorperazine (Compro) and they typically go away when you stop the medication. Talk with your healthcare team right away if you experience these symptoms, you might need to lower your dose of prochlorperazine (Compro) or switch to a different medication.
Prochlorperazine (Compro) can cause neuroleptic malignant syndrome (NMS), which is a rare but serious condition that can lead to death. Symptoms include a very high fever, stiff muscles, problems thinking clearly, very fast or uneven heartbeat, and sweating. Stop taking prochlorperazine (Compro) and get medical attention right away if you experience these symptoms. Be careful using prochlorperazine (Compro) if you're also on other medications that might cause NMS, such as antipsychotics.
Prochlorperazine (Compro) can cover up more serious health problems. It eases nausea and vomiting, which covers up conditions such as drug overdose or poisoning. It might cause side effects such as sleepiness, confusion, and difficulty controlling muscle movements, which can be confused with conditions such as brain damage, brain tumor, or Reye's syndrome (a rare, but serious condition seen in children and teens recovering from viral infections). Children and teenagers who might have Reye’s syndrome should not use this medication.
Prochlorperazine (Compro) can cause low white blood cell counts, which might lead to serious infection and in some cases, death. You might need to get lab work done regularly to make sure your white blood cell count is healthy. Talk to your healthcare team right away if you experience symptoms of an infection, such as fever, weakness, or sore throat, while you're taking this medication.
Prochlorperazine (Compro) can cause low blood pressure, which might lead to fainting and falling. If you need to stand up or sit up, do so slowly. Talk to your healthcare provider if you continue to experience dizziness while taking prochlorperazine (Compro).
Prochlorperazine (Compro) might cause serious liver problems. Talk to your healthcare provider right away if you experience symptoms such as fever, chills, yellowing of the skin or whites of the eyes, clay-colored stool, and dark urine.
Taking prochlorperazine (Compro) puts you at higher risk for seizures. Talk to your healthcare provider if you have a history of seizures because your dose of seizure medications might need to be adjusted. Be careful driving, swimming, or participating in other potentially dangerous activities in which sudden loss of consciousness could cause serious harm.
Prochlorperazine (Compro) can cause prolactin hormone levels in your blood to go up. High prolactin levels can lead to symptoms such as milky substances being released from the nipple, enlarged breasts, and absent or irregular menstrual periods. Talk to your healthcare provider if you experience or have any concerns about these symptoms.
Prochlorperazine (Compro) might make it hard for your body to maintain a normal body temperature. Be careful if you are traveling to a place that is very hot.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 25mg | 12 suppositories | $30.28 | $2.52 |
Your dose might be lower if you're an older adult, not able to move around, or at risk for certain health conditions, like low blood pressure.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Prochlorperazine (Compro) will not be safe for you to take.