Key takeaways
Ondansetron (Zofran) and Sustol (granisetron) are both antiemetic medications used to prevent nausea and vomiting, particularly related to chemotherapy. Ondansetron is available in multiple forms, including tablets, orally disintegrating tablets, liquid, and injections, and can be used by both adults and children. In contrast, Sustol is available as a tablet and injection and is specifically for adults. Ondansetron needs to be taken multiple times a day, while the Sustol injection lasts up to 7 days with a single injection. Ondansetron can be used off-label during pregnancy, but the safety of Sustol in pregnant or breastfeeding women is not clear. Additionally, Sustol cannot be used in children, whereas ondansetron can. Both medications can cause side effects like headache and constipation, but Sustol has a higher risk of injection site reactions.
