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Compare Kytril vs. Zofran

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Granisetron
    Ondansetron (Zofran)
  • Granisetron
    Ondansetron (Zofran)

  • Summary of Kytril vs. Zofran

    Summary for Antiemetic
    Prescription only

    Granisetron prevents nausea and vomiting due to chemotherapy and radiation. It can cause headaches and can be more expensive than other similar medications like ondansetron (Zofran).

    Summary for Antiemetic
    Prescription only

    Ondansetron (Zofran) is an antiemetic (or anti-nausea) medication. It's used to prevent nausea and vomiting after surgery or cancer treatments. It works by stopping a chemical called serotonin from binding to receptors in the brain that cause the feeling of nausea and vomiting. Ondansetron (Zofran) is taken by mouth, typically every 8 to 12 hours. It comes in different formulations, including orally disintegrating tablet (ODT) and oral solution. It can also be given as injection by a healthcare professional (HCP) in a hospital setting. Side effects of this medication include headache, tiredness, and constipation or diarrhea.

  • Indications of Kytril vs. Zofran

    Indications for
    •Prevention of nausea and vomiting associated with cancer medications (chemotherapy) and radiation
    Indications for
    •Prevention of nausea and vomiting due to cancer medications (chemotherapy) or radiation therapy
    •Prevention of nausea and vomiting after surgery

  • Pros and Cons of Kytril vs. Zofran

    Pros and Const for Antiemetic
    Pros
    •Can be taken orally or by injection
    •Safe option for older adults and people with kidney and liver problems
    •Only needs to be taken on chemotherapy and radiation days
    Cons
    •Only prevents nausea and vomiting; not as good of an option for treatment of nausea and vomiting that is already present
    •Tablets not for use in children
    •Can be more expensive than similar medications
    Pros and Const for Antiemetic
    Pros
    •Can use for both adults and children
    •Available as a lower-cost generic
    •Available as a liquid, dissolvable tablet, and injection for people who have problems swallowing pills or are too nauseous to keep medication down
    •Possible option during pregnancy and breastfeeding
    Cons
    •Needs to be taken multiple times daily
    •Might cause headache
    •Can interact with certain medications, like antidepressants and migraine medications
    •Not the best option for people who are at risk for stomach or gut blockages (bowel problems)

  • Common Side Effects of Kytril vs. Zofran

    Common Side Effects for
    •Headache (20%)
    •Weakness or lack of energy (18%)
    •Constipation (14%)
    •Diarrhea (9%)
    •Upset stomach and stomach pain (4—6%)
    Common Side Effects for
    •Headache (up to 24%)
    •Fatigue (up to 13%)
    •Constipation (up to 9%)
    •Diarrhea (up to 6%)

  • Warnings of Kytril vs. Zofran

    Common Side Effects for
    •Serotonin syndrome
    •Heart rhythm problems
    •Digestion problems
    Common Side Effects for
    •Severe allergic reactions
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Serotonin syndrome
    •Risk of heart attack
    •Masking of gut blockage and stomach bloating
    •Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

  • Prices with our coupons for Kytril vs. Zofran

    Learn more about Granisetron
    Learn more about Ondansetron

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