Key takeaways
Ondansetron (Zofran) and prochlorperazine (Compazine) are both used to treat nausea and vomiting, but they have some key differences. Ondansetron is an antiemetic that works by blocking serotonin in the brain, while prochlorperazine is a phenothiazine that blocks dopamine. Ondansetron is available in various forms, including tablets, dissolvable tablets, oral solution, and injections, and is typically taken every 8 to 12 hours. Prochlorperazine, on the other hand, is usually taken 3 to 4 times daily and is also used to treat schizophrenia and generalized anxiety disorder. Ondansetron is considered safer during pregnancy, although it is not FDA-approved for this use, whereas prochlorperazine is not recommended during pregnancy due to potential risks to the baby. Prochlorperazine can cause serious side effects like uncontrolled muscle movements and extreme sleepiness, making it less favorable for long-term use. Both medications are available in generic forms, making them more affordable options.
