Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Bonjesta vs. Zofran

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Bonjesta (doxylamine/pyridoxine) and Zofran (ondansetron) are both medications used to treat nausea and vomiting, but they are used in different situations. Bonjesta is specifically FDA-approved for morning sickness during pregnancy, while Zofran is approved for preventing nausea and vomiting after surgery or cancer treatments. Bonjesta combines an antihistamine (doxylamine) and a dietary supplement (pyridoxine, or vitamin B6), whereas Zofran is an antiemetic that works by blocking serotonin in the brain. Bonjesta is taken as a tablet, typically once or twice a day, and does not have a generic version available. Zofran, on the other hand, is available in multiple forms, including tablets, orally disintegrating tablets, and injections, and it does have a generic version. Common side effects of Bonjesta include sleepiness, while Zofran can cause headaches and fatigue. Additionally, Zofran has potential interactions with medications that affect serotonin levels, which can lead to a serious condition called serotonin syndrome.

  • Bonjesta (doxylamine / pyridoxine)
    Ondansetron (Zofran)
  • Bonjesta (doxylamine / pyridoxine)
    Ondansetron (Zofran)

  • Summary of Bonjesta vs. Zofran

    Summary for Antihistamine / Dietary supplement
    Prescription only

    Bonjesta (doxylamine / pyridoxine) treats morning sickness, or nausea and vomiting that happens during pregnancy. It's typically taken when changing your diet or staying away from nausea triggers isn't enough help. This medication contains an antihistamine called doxylamine and a dietary supplement called pyridoxine (also known as vitamin B6). The dosage is 1 tablet taken by mouth at bedtime, but it can be adjusted to 1 tablet in the morning and 1 tablet at bedtime if needed. This medication commonly causes sleepiness as a side effect.

    Summary for Antiemetic
    Prescription only

    Ondansetron (Zofran) is an antiemetic (or anti-nausea) medication. It's used to prevent nausea and vomiting after surgery or cancer treatments. It works by stopping a chemical called serotonin from binding to receptors in the brain that cause the feeling of nausea and vomiting. Ondansetron (Zofran) is taken by mouth, typically every 8 to 12 hours. It comes in different formulations, including orally disintegrating tablet (ODT) and oral solution. It can also be given as injection by a healthcare professional (HCP) in a hospital setting. Side effects of this medication include headache, tiredness, and constipation or diarrhea.

  • Indications of Bonjesta vs. Zofran

    Indications for
    •Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief
    Indications for
    •Prevention of nausea and vomiting due to cancer medications (chemotherapy) or radiation therapy
    •Prevention of nausea and vomiting after surgery

  • Pros and Cons of Bonjesta vs. Zofran

    Pros and Const for Antihistamine / Dietary supplement
    Pros
    •One of the few medications that's FDA approved for morning sickness during pregnancy
    •Combines two medications into one tablet for convenience
    •Dose ranges from 1 to 2 tablets per day, depending on your needs
    Cons
    •Can cause sleepiness
    •Not for severe nausea and vomiting during pregnancy (hyperemesis gravidarum)
    •Not known whether it works well or is safe for people under 18 years old
    Pros and Const for Antiemetic
    Pros
    •Can use for both adults and children
    •Available as a lower-cost generic
    •Available as a liquid, dissolvable tablet, and injection for people who have problems swallowing pills or are too nauseous to keep medication down
    •Possible option during pregnancy and breastfeeding
    Cons
    •Needs to be taken multiple times daily
    •Might cause headache
    •Can interact with certain medications, like antidepressants and migraine medications
    •Not the best option for people who are at risk for stomach or gut blockages (bowel problems)

  • Common Side Effects of Bonjesta vs. Zofran

    Common Side Effects for
    •Sleepiness (14%)
    Common Side Effects for
    •Headache (up to 24%)
    •Fatigue (up to 13%)
    •Constipation (up to 9%)
    •Diarrhea (up to 6%)

  • Warnings of Bonjesta vs. Zofran

    Common Side Effects for
    •Sleepiness
    •Worsening of certain other medical conditions
    Common Side Effects for
    •Severe allergic reactions
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Serotonin syndrome
    •Risk of heart attack
    •Masking of gut blockage and stomach bloating
    •Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

  • Prices with our coupons for Bonjesta vs. Zofran

    Learn more about Bonjesta
    Learn more about Ondansetron

Compare other Morning Sickness and Nausea drugs

Bonjesta vs ZofranBarhemsys vs ZofranCompazine vs ReglanDiclegis vs PhenerganDiclegis vs ZofranDramamine vs ZofranEmend vs ReglanGranisetron vs ReglanKytril vs ZofranMeclizine vs ZofranPhenergan vs AnzemetPhenergan vs ComproSancuso vs ReglanScopolamine vs AnzemetScopolamine vs ComproSustol vs ReglanTigan vs ZofranZofran vs AnzemetZofran vs CompazineZofran vs ComproZofran vs DexamethasoneZofran vs EmendZofran vs GranisetronZofran vs Pepto BismolZofran vs PhenerganZofran vs ReglanZofran vs SancusoZofran vs ScopolamineZofran vs SustolZyprexa vs Reglan
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.