Vitamin B6 (pyridoxine) is a dietary supplement. It's used to treat vitamin B6 deficiency (low levels of vitamin B6) in children and adults. It's usually taken by mouth once daily. But unless directed by your provider, most people don't need to take vitamin B6 (pyridoxine) supplement because they get enough of it through foods like chicken, tuna, or chickpeas. Providers sometimes also recommend vitamin B6 (pyridoxine) for off-label uses, such as treating morning sickness during pregnancy. This supplement isn't likely to cause side effects if you take it as directed at the recommended doses.
Low levels of vitamin B6
Vitamin B6 (pyridoxine) is a dietary supplement. It's a water-soluble vitamin. This means that your body doesn't typically store a lot of it, but passes the extra through urine. Vitamin B6 plays an important role in many different reactions that help provide your body with energy.
This supplement helps give you vitamin B6 when you don't get enough from your diet or have health conditions that cause you to have a low vitamin B6 level.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Few side effects
Safe option for nausea and vomiting during pregnancy
Available over the counter as pills and liquid solutions
Possible to take too much of this supplement, which can lead to serious side effects
Injection form is only available with a prescription
When choosing an OTC vitamin B6 (pyridoxine) product, look for special markings from the United States Pharmacopeia (USP) or National Sanitation Foundation (NSF). These markings mean the particular product has gone through special testing to check for the purity of the product.
Many multivitamins already contain vitamin B6. So make sure you check how much you should be taking with your provider to avoid side effects from taking too much of the vitamin, such as numbness and tingling in the fingers and toes.
Make sure to tell your provider or pharmacist about all of the medications you're taking, because vitamin B6 (pyridoxine) might interact with your other medications.
Don't take vitamin B6 (pyridoxine) anytime after the expiration date on the package because it might not work as well.
Keep the medication bottle in a cool, dry place at room temperature. Don't store it in your bathroom because the moisture in the air could affect the medication.
Store this medication away from children. If your child takes vitamin B6 (pyridoxine) by accident, you might need to contact poison control (1-800-222-1222) right away.
Vitamin B6 (pyridoxine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Taking more than the recommended dose
It's possible to take too much vitamin B6 (pyridoxine), which can cause serious side effects. Follow your healthcare provider's instructions for how to take this supplement properly. If you experience numbness in your hands or legs, poor muscle control, unsteadiness, bone pain, or any other nerve issues, get medical help right away.
Vitamin B6 (pyridoxine) is available in different strengths and dosage forms. Make sure to follow the package directions and ask your pharmacist. The dosing below is for the tablets containing 50 mg of pyridoxine.
Adults and children 12 years and older: The typical dose is 1 tablet by mouth daily, or as directed by your healthcare provider.
Vitamin B6 (pyridoxine) is also available by prescription as an IV (in the vein) and IM (in the muscle) injection. Injections are typically given by a healthcare provider.
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American College of Obstetricians and Gynecologists. (2023). Morning sickness: Nausea and vomiting of pregnancy.
American Pregnancy Association. (n.d.). Natural sources of vitamin B during pregnancy.
Brown, M. J., et al. (2023). Vitamin B6 deficiency. StatPearls.
Fresenius Kabi USA, LLC. (2019). Pyridoxine hydrochloride injection, solution [package insert]. DailyMed.
Hemminger, A., et al. (2023). Vitamin B6 toxicity. StatPearls.
Herrell, H. E., et al. (2014). Nausea and vomiting of pregnancy. American Family Physician.
Lykstad, J., et al. (2023). Biochemistry, water soluble vitamins. StatPearls.
Marlex Pharmaceuticals Inc. (2020). B-6 pyridoxine HCl- pyridoxine hydrochloride tablet [package insert]. DailyMed.
National Institutes of Health, Office of Dietary Supplements. (2023). Vitamin B6: Fact sheet for consumers.
National Institutes of Health, Office of Dietary Supplements. (2023). Vitamin B6: Fact sheet for health professionals.
NSF. (n.d.). Supplement and vitamin certification.
United States Pharmacopeia. (n.d.). USP verified mark.
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