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Doxylamine / Pyridoxine Coupon - Doxylamine / Pyridoxine 10mg/10mg tablet

doxylamine / pyridoxine

Generic Diclegis
Used for Morning Sickness
Used for Morning Sickness

Diclegis (doxylamine / pyridoxine) helps treat morning sickness, or nausea and vomiting that people experience during pregnancy. It's typically taken when changing your diet or avoiding nausea triggers isn't enough. This medication contains an antihistamine called doxylamine and a dietary supplement called pyridoxine (also known as vitamin B6). The dosage starts at 2 tablets taken by mouth at bedtime, but it can be adjusted if you need more relief. A common side effect is sleepiness. This medication has a brand-name and generic version.

Reviewed by:
reviewer
Cydnee Ng, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on November 12, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Diclegis (doxylamine / pyridoxine)?

What is Diclegis (doxylamine / pyridoxine) used for?

  • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

How Diclegis (doxylamine / pyridoxine) works

Diclegis (doxylamine / pyridoxine) is a combination of two medications that are thought to work together to relieve symptoms of morning sickness.

  • Doxylamine is an antihistamine. It blocks histamine, a natural chemical in the body, from turning on the part of the brain that's responsible for nausea and vomiting.

  • Pyridoxine, another name for vitamin B6, is a dietary supplement. It's not clear how pyridoxine helps lessen nausea and vomiting during pregnancy.

Are you looking for information on Bonjesta (doxylamine / pyridoxine) instead?
When does Diclegis (doxylamine / pyridoxine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsDiclegis
Drug ClassAntihistamine / Dietary supplement
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$312.94(save 47.29%)
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$164.96
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What are the side effects of Diclegis (doxylamine / pyridoxine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness (14%)

Other Side Effects

  • Stomach pain
  • Constipation
  • Diarrhea
  • Chest discomfort
  • Tiredness
  • Dizziness
  • Headache
  • Balance problems
  • Blurry vision

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Accidentally taking too much medication: extreme sleepiness, dry mouth, restlessness, feeling like your surroundings are spinning, fast heart rate, confusion
When do Diclegis (doxylamine / pyridoxine) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Sleepiness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Blurred or loss of vision

burning feeling while urinating

chest discomfort

decrease in the frequency of urination

decrease in urine volume

difficult or labored breathing

difficult or painful urination

disturbed color perception

double vision

fast, irregular, pounding, or racing heartbeat or pulse

fever

halos around lights

headache, severe and throbbing

hives, itching, skin rash

hoarseness

irritation

joint pain, stiffness, or swelling

night blindness

overbright appearance of lights

redness of the skin

stomach distension or pain

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

troubled breathing or swallowing

tunnel vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Unusual drowsiness

Incidence not known

Anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

confusion about identity, place, and time

constipation

diarrhea

dizziness or lightheadedness

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

headache

increased sweating

irritability

nightmares

sensation of spinning

trouble sleeping

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Diclegis (doxylamine / pyridoxine)

thumbs-up

Pros

One of the few medications that's FDA approved for morning sickness during pregnancy

Combines two medications into one tablet for convenience

Dose can be adjusted based on response

thumbs-down

Cons

Dose ranges from 2 to 4 tablets per day, depending on your needs

Not for severe nausea and vomiting during pregnancy (hyperemesis gravidarum)

Not known whether it works well or is safe for people under 18 years old

pharmacist-tips

Pharmacist tips for Diclegis (doxylamine / pyridoxine)

pharmacist

  • It's best to take Diclegis (doxylamine / pyridoxine) on an empty stomach with a full glass of water. Taking it soon after eating can make the medication take longer to work.

    • Swallow Diclegis (doxylamine / pyridoxine) tablets whole. Don't crush, chew, or break the tablets before swallowing. Otherwise, the medication might not last as long in your system.

      • Diclegis (doxylamine / pyridoxine) can make you sleepy. Avoid driving or doing activities that you need to pay attention to until you speak with your prescriber after you start taking this medication. It's dangerous to drive when you're sleepy and have trouble thinking clearly or reacting quickly.

        • Avoid taking other medications that contain an antihistamine while you're taking Diclegis (doxylamine / pyridoxine). This can raise your risk for serious side effects, like extreme sleepiness and confusion. Many over-the-counter allergy, cough and cold medications, and sleep aids can contain antihistamines. Ask your pharmacist if you're not sure which medications contain antihistamines.

          • Share a list of medications that you're taking with your prescriber so they can check for harmful interactions. It's not recommended to take Diclegis (doxylamine / pyridoxine) if you're taking other medications that make you sleepy, such as muscle relaxers, sleep aids, and anxiety medications. It can cause severe sleepiness, which can lead to accidents and falls.

            • Other tips to help with morning sickness include drinking enough water during the day and eating dry crackers in bed in the morning so you're not moving around on an empty stomach. In addition, eat five or six smaller meals instead of a few larger meals throughout the day. Your stomach might be able to handle smaller portions of food better. You can also try ginger candies, ginger ale, and ginger tea.

              faqs

              Frequently asked questions about Diclegis (doxylamine / pyridoxine)

              Can you take Diclegis (doxylamine / pyridoxine) if you're not pregnant?
              Diclegis (doxylamine / pyridoxine) isn't FDA approved for relieving nausea and vomiting in people who aren't pregnant. It's only approved for morning sickness, or nausea and vomiting that people experience when they're pregnant. Speak with a healthcare professional if you feel nauseous or are vomiting and you're not pregnant. They can recommend other medications for you. They can also recommend tips, like sticking to a bland diet for a short while to make sure you're eating without upsetting your stomach.
              Can I take doxylamine and pyridoxine separately instead of Diclegis (doxylamine / pyridoxine)?
              Yes. In fact, the American College of Obstetricians and Gynecologists (ACOG) recommends pyridoxine (also known as vitamin B6) by itself as a first-choice option for morning sickness. If you need more relief, they recommend adding on doxylamine or switching to Diclegis (doxylamine / pyridoxine). If you take the two separately, a common dose is 10 mg to 25 mg of pyridoxine, with or without 12.5 mg of doxylamine, three to four times a day. You can find pyridoxine and doxylamine over the counter as single ingredients. Keep in mind that doxylamine comes as 25 mg tablets only, so you'll need to cut them in half with a pill splitter for your doses. Ask a healthcare professional about whether this option is right for you instead of Diclegis (doxylamine / pyridoxine).
              Are Diclegis and Bonjesta the same?
              Not quite, but they're very similar. The brand-name medications Diclegis and Bonjesta contain the same active ingredients, doxylamine and pyridoxine (also known as vitamin B6). Diclegis tablets contain 10 mg of doxylamine and 10 mg of pyridoxine. But Bonjesta tablets contain double the amount of the ingredients (20 mg of doxylamine and 20 mg of pyridoxine). In general, you need to take less tablets with Bonjesta than with Diclegis (for example, 1 Bonjesta tablet at bedtime versus 2 Diclegis tablets at bedtime). There's also a generic version of Diclegis but not for Bonjesta. Compare the two medications and discuss with your prescriber about which option is right for you.
              How much vitamin B6 is in Diclegis (doxylamine / pyridoxine)?
              Each tablet of Diclegis contains 10 mg of vitamin B6 (also known as pyridoxine). There's also 10 mg of doxylamine in each tablet. Vitamin B6 and doxylamine work together to relieve morning sickness during pregnancy.
              Does Diclegis (doxylamine / pyridoxine) make you tired or sleepy?
              Yes. In fact, the most common side effect of Diclegis (doxylamine / pyridoxine) is sleepiness. It's possible for the medication to also make you feel tired. Avoid driving or doing anything that you need to concentrate for until you talk with your prescriber after you start taking Diclegis (doxylamine / pyridoxine). It can be dangerous to do these things when you're sleepy and have trouble thinking clearly or reacting quickly.
              Can you find Diclegis (doxylamine / pyridoxine) over the counter?
              No, Diclegis (doxylamine / pyridoxine) isn't available over the counter (OTC). You'll need to get it from a pharmacy with a prescription written by a healthcare professional.
              How long does it take for Diclegis (doxylamine / pyridoxine) to work?
              It typically takes several hours (4 to 6 hours) for each dose of Diclegis (doxylamine / pyridoxine) to work to lessen nausea and vomiting during pregnancy. You first start taking the medication at bedtime so that it starts working early in the morning the next day. If you need to take the medication at additional times of the day, those extra doses would help provide relief throughout the day. In a clinical study, it took up to 2 weeks for people between 7 and 14 weeks of pregnancy who took Diclegis (doxylamine / pyridoxine) to notice significant improvement in their morning sickness. Ask your prescriber if you have questions about how long it's taking for Diclegis (doxylamine / pyridoxine) to work for you.
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              What are the risks and warnings for Diclegis (doxylamine / pyridoxine)?

              Diclegis (doxylamine / pyridoxine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Sleepiness

              • Risk factors: Taking medications that can make you sleepy | Drinking alcohol

                Diclegis (doxylamine / pyridoxine) can make you sleepy. To prevent accidental injuries, avoid driving, operating heavy machinery, or doing anything that you need concentration for while you're taking this medication until you speak with your prescriber. Discuss with them about how Diclegis (doxylamine / pyridoxine) affects your ability to think clearly and react quickly.

                Diclegis (doxylamine / pyridoxine) isn't recommended if you're currently taking other medications that can make you sleepy, such as sleep or anxiety medications, or if you drink alcohol. Mixing Diclegis (doxylamine / pyridoxine) with these medications or with alcohol can lead to severe sleepiness, which can lead to falls or accidents.

                risk-warning

                Worsening of certain other medical conditions

                Because of how Diclegis (doxylamine / pyridoxine) works and its possible side effects, this medication can worsen symptoms of some other medical conditions. These conditions can include high pressure in the eye, narrow-angle glaucoma, stomach ulcers, gut blockage, and problems with urination. Let your care team know about your full medical history before you start taking Diclegis (doxylamine / pyridoxine) so they can discuss risks and benefits.

                Contact your primary care provider or care team if you notice any symptoms of your other medical conditions get worse while you're taking Diclegis (doxylamine / pyridoxine).

                dosage

                Diclegis (doxylamine / pyridoxine) dosage forms

                The average cost for 60 tablets of 10mg/10mg of Diclegis (doxylamine / pyridoxine) is $164.96 with a free GoodRx coupon. This is 47.29% off the average retail price of $312.94.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                10mg/10mg60 tablets$164.96$2.75

                Typical dosing for Diclegis (doxylamine / pyridoxine)

                Each tablet contains 10 mg of doxylamine and 10 mg of pyridoxine.

                The starting dose is 2 tablets by mouth at bedtime on an empty stomach.

                • If your symptoms don't get better after the second day of taking the medication, you can take 1 tablet by mouth in the morning and then 2 tablets at bedtime. Take the medication on an empty stomach.

                • If you're still having symptoms after several days, you can take 1 tablet by mouth in the morning, 1 tablet in the afternoon, and 2 tablets at bedtime. Take the medication on an empty stomach.

                The maximum number of tablets you can take in a day is 4 tablets.

                interactions

                Interactions between Diclegis (doxylamine / pyridoxine) and other drugs

                Diclegis (doxylamine / pyridoxine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Diclegis (doxylamine / pyridoxine). Please note that only the generic name of each medication is listed below.

                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                How much does Diclegis (doxylamine / pyridoxine) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                Diclegis (brand)
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                contraindications-icon

                Diclegis (doxylamine / pyridoxine) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Diclegis (doxylamine / pyridoxine) will not be safe for you to take.
                alternatives

                What are alternatives to Diclegis (doxylamine / pyridoxine)?

                There are a number of medications that your doctor can prescribe in place of Diclegis (doxylamine / pyridoxine). Compare a few possible alternatives below.
                Diclegis (doxylamine / pyridoxine)
                Used for:

                • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

                $164.96 Lowest GoodRx priceView Prices
                Bonjesta (doxylamine / pyridoxine)
                Used for:

                • Morning sickness (nausea and vomiting during pregnancy) when non-medication options haven't provided enough relief

                $269.83 Lowest GoodRx priceView Prices
                images

                Diclegis (doxylamine / pyridoxine) images

                White Round M Dp - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                This medicine is White, Round Tablet Imprinted With "M Dp".White Round M Dp - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                White Round 2132 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                This medicine is White, Round Tablet Imprinted With "2132".White Round 2132 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                White Round 186 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                This medicine is White, Round Tablet Imprinted With "186".White Round 186 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                White Round Dp 1 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                This medicine is White, Round Tablet Imprinted With "Dp 1".White Round Dp 1 - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                White Round Logo - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet
                This medicine is White, Round Tablet Imprinted With "Logo".White Round Logo - Doxylamine Succinate and Pyridoxine Hydrochloride 10mg-10mg Delayed-Release Tablet

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                References

                Best studies we found

                Actavis Pharma, Inc. (2023). Doxylamine succinate and pyridoxine hydrochloride tablet, delayed release [package insert]. DailyMed.

                American College of Obstetricians and Gynecologists. (2023). Morning sickness: Nausea and vomiting of pregnancy.

                American Optometric Association. (n.d.). Ocular hypertension.

                View All References (8)

                Duchesnay USA, Inc. (2024). Diclegis- doxylamine succinate and pyridoxine hydrochloride tablet, delayed release [package insert]. DailyMed.

                Madjunkova, S., et al. (2014). The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin®) for the treatment of nausea and vomiting of pregnancy. Paediatric Drugs.

                MedlinePlus. (2017). Intestinal obstruction.

                MedlinePlus. (2024). Bladder outlet obstruction.

                National Institutes of Health. (2023). Vitamin B6: Fact sheet for consumers. 

                Nuangchamnong, N., et al. (2014). Doxylamine succinate-pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: An overview. International Journal of Women's Health.

                Persaud, N., et al. (2018). Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. Public Library of Science One.

                U.S. Food and Drug Administration. (2024). Beyond morning sickness: Hyperemesis gravidarum.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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