dimenhydrinate
Dimenhydrinate is an over-the-counter medication that helps prevent and treat nausea, vomiting, or dizziness from motion sickness. It's a type of antihistamine and anticholinergic medication. It has many brand names, including Dramamine and Dramamine For Kids, and is also available as a generic. Dimenhydrinate comes as tablets, chewable tablets, and a syrup. The dosage depends on your age and the form of the medication you're using. It's usually taken a few times a day as needed. Side effects include feeling drowsy, dizzy, and constipated.
What is Dimenhydrinate?
What is Dimenhydrinate used for?
Prevention and treatment of nausea, vomiting, or dizziness from motion sickness
How Dimenhydrinate works
Dimenhydrinate is a first-generation antihistamine. It also has anticholinergic effects.
This medication blocks two chemicals in the brain called histamine and acetylcholine. It stops these chemicals from turning on the part of the brain that causes nausea and vomiting. This helps prevent and treat nausea and other symptoms of motion sickness.
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What are the side effects of Dimenhydrinate?
Common Side Effects
- Sleepiness
- Dizziness
- Dry mouth
- Constipation
- Blurry vision
Other Side Effects
- Headache
- Trouble urinating
Source: DailyMed
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The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Confusion
- Constipation
- Dizziness
- Drowsiness
- Dry mouth
Pros and cons of Dimenhydrinate
Pros
Helps both prevent and treat symptoms of motion sickness
Available over the counter as oral tablets, chewable tablets, or syrup
Okay for children as young as 2 years old to take
Cons
Can make you sleepy or dizzy
Might need to take as often as every 4 to 6 hours for lasting prevention or symptom relief
Not the best choice for people over 65 years old, people with glaucoma, or people with problems urinating
Pharmacist tips for Dimenhydrinate
You can take dimenhydrinate with or without food.
To prevent motion sickness: Take your first dose of dimenhydrinate 30 minutes to 1 hour before you travel or do something that causes motion sickness.
For the dimenhydrinate chewable tablets: Make sure to chew the tablet completely before swallowing. Don't swallow them whole.
For the dimenhydrinate regular tablets: Swallow the tablet whole.
For the dimenhydrinate syrup: Store the bottle at room temperature. Use a medication dose cup or an oral syringe to measure out the dose. Don't use household spoons because they aren't accurate and using them might cause you to take the wrong dose.
Dimenhydrinate can make you sleepy, dizzy, and have blurry vision. Don't drive or do anything that needs your focus until you know how this medication affects you.
Don't drink alcohol while taking dimenhydrinate. It can make side effects stronger.
You might have dry mouth while you're taking dimenhydrinate. To help with dry mouth, you can suck on ice, chew sugar-free gum, or rinse your mouth with cold water. You can also try using saliva substitutes, which come as sprays and lozenges.
Some people might get constipated after taking dimenhydrinate. You can help prevent this by drinking plenty of water and eating more fiber-rich foods. Ask your care team if you need help with constipation.
Don't start any new medications while taking dimenhydrinate without talking to a pharmacist or healthcare professional first. This is especially important for medications that contain antihistamines. Taking more than one antihistamine medication at the same time can be dangerous. It can raise your risk of taking too much (overdose), which can lead to serious side effects.
If you're breastfeeding, ask your obstetrician-gynecologist (OB-GYN) or lactation specialist if dimenhydrinate is safe for you. Small, occasional doses usually aren't harmful to your baby. But taking larger amounts or taking it often might lower your milk supply and could side effects in your baby.
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Frequently asked questions about Dimenhydrinate
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What are the risks and warnings for Dimenhydrinate?
Dimenhydrinate can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness
Risk factors: Age 65 or older | Taking other medications that cause sleepiness | Drinking alcohol
Dimenhydrinate can make you very sleepy. This can make it harder to focus, think clearly, or react fast. This side effect is more likely to happen or be stronger if you're 65 years or older. It can also be worse if you drink alcohol or take other medications that can make you sleepy, like benzodiazepines or sleep medications. Don't drive or use machinery until you know how dimenhydrinate affects you.
Worsening of certain medical conditions
Risk factors: Breathing problems (e.g., asthma, chronic bronchitis) | Glaucoma | Urinary conditions
Ask a healthcare professional if you can take dimenhydrinate if you have breathing problems like asthma, glaucoma, or trouble urinating from an enlarged prostate. This medication can make these problems worse. A healthcare professional can help make sure dimenhydrinate is safe for you.
Accidentally taking too much medication (accidental overdose)
Taking more than one medication with an antihistamine in it can raise your risk of taking too much. Dimenhydrinate is an antihistamine. And many allergy, cough, and cold medications also have antihistamines.
Early signs of an accidental overdose include having stronger side effects. But it can also lead to serious problems like fast heartbeat, confusion, poor balance, seizures, or even death. If this happens, get medical help or call a poison control center at 1-800-222-1222 right away.
To stay safe, tell your healthcare team about all the medications you take. Don't start any new medications without checking with them first. Always read package labels carefully. Ask a pharmacist if you're not sure if a product has an antihistamine.
Use with caution in people with phenylketonuria (PKU) - chewable tablets only
Dimenhydrinate chewable tablets contain phenylalanine, a component of the artificial sweetener aspartame. If you have a genetic condition called phenylketonuria (PKU), the chewable tablets can be harmful for you. Tell a healthcare professional if you have PKU. They can help you find a different form of dimenhydrinate or a different medication that's safer for you.
Dimenhydrinate dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 50mg | 24 tablets | $5.39 | $0.22 |
Typical dosing for Dimenhydrinate
Note: There are many brands, manufacturers, and forms of dimenhydrinate. Each one can have different amounts of medication, so the typical dosage can be different. Read the label for the right instructions for your product.
A few dosing examples are listed below.
Dimenhydrinate 50 mg oral tablet or dimenhydrinate 50 mg chewable tablet: Swallow oral tablets whole. Chew or crush the chewable tablets before swallowing.
Age 12 years and up: The typical dose is 1 to 2 tablets every 4 to 6 hours as needed. Don't take more than 8 tablets in a 24-hour period.
Age 6 years to under 12 years: The typical dose is half a tablet to 1 tablet every 6 to 8 hours as needed. Don't give more than 3 tablets in a 24-hour period.
Age 2 years to under 6 years: The typical dose is half a tablet every 6 to 8 hours as needed. Don't give more than 1.5 tablets in a 24-hour period.
Age under 2 years: Don't use. Ask a healthcare professional.
Dimenhydrinate 25 mg chewable tablet
Age 6 years to under 12 years: The typical dose is to chew 1 to 2 tablets every 6 to 8 hours as needed. Don't use more than 6 tablets in a 24-hour period.
Age 2 years to under 6 years: The typical dose is to chew half a tablet to 1 tablet every 6 to 8 hours as needed. Don't use more than 3 tablets in a 24-hour period.
Age under 2 years: Don't use. Ask a healthcare professional.
Dimenhydrinate syrup Each 5 mL contains 15 mg of dimenhydrinate.
Age 6 years to under 12 years: The typical dose is 2 teaspoonfuls (10 mL) by mouth every 6 to 8 hours as needed. Don't use more than 10 teaspoons (50 mL) in a 24-hour period.
Age 2 years to under 6 years: The typical dose is 1 teaspoonful (5 mL) by mouth every 4 to 6 hours as needed. Don't use more than 5 teaspoons (25 mL) in a 24-hour period.
Age under 2 years: Don't use. Ask a healthcare professional.
Dimenhydrinate is also available as an injection that's administered by a healthcare professional for people in the hospital.
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How much does Dimenhydrinate cost?
What are alternatives to Dimenhydrinate?
Prevention and treatment of nausea, vomiting, or dizziness from motion sickness
Over-the-counter (OTC) dimenhydrinate: Nausea, vomiting, or dizziness from motion sickness
Prescription dimenhydrinate: Vertigo (feeling like your surroundings are moving or spinning)
Prevention of nausea and vomiting due to:
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References
Best studies we foundBorowy, C. S., et al. (2023). Antihistamine toxicity. StatPearls.
Church & Dwight Co., Inc. (2024). Gravol- dimenhydrinate syrup [package insert]. DailyMed.
Drugs and Lactation Database (LactMed®). (2021). Dimenhydrinate. National Institute of Child Health and Human Development.
Fresenius Kabi USA, LLC. (2025). Dimenhydrinate injection, solution [package insert]. DailyMed.
Hunter, B. R., et al. (2022). Efficacy of benzodiazepines or antihistamines for patients with acute vertigo: A systematic review and meta-analysis. Journal of the American Medical Association Neurology.
LEADER/ Cardinal Health 110, Inc. (2025). Dimenhydrinate tablet [package insert]. DailyMed.
Lil’ Drug Store Products, Inc. (2024). Dramamine- dimenhydrinate tablet, chewable; Dramamine, Travel Basix- dimenhydrinate tablet, chewable [package insert]. DailyMed.
Medtech Products Inc. (2024). Dramamine for Kids- dimenhydrinate tablet, chewable [package insert]. DailyMed.
National Human Genome Research Institute. (2014). About phenylketonuria.
Oh, H., et al. (2022). Cybersickness and its severity arising from virtual reality content: A comprehensive study. Sensors.
Patel, P. N., et al. (2011). Meclizine: Safety and efficacy in the treatment and prevention of motion sickness. Clinical Medicine Insights: Therapeutics.
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