Meclizine is an antihistamine. It's used to prevent and treat nausea, vomiting, and dizziness from motion sickness or vertigo. It's available in both prescription (to treat vertigo) and over-the-counter (to treat motion sickness) forms. Meclizine also comes as a chewable tablet or pill that you swallow whole. Some common side effects of meclizine include sleepiness, dry mouth, and difficulty urinating.
Over-the-counter (OTC) meclizine: Nausea, vomiting, or dizziness from motion sickness
Prescription meclizine: Vertigo (feeling like your surroundings are moving or spinning)
Meclizine is an antihistamine. It blocks histamine, a natural chemical in your body, from binding (attaching) to a part of your brain that triggers nausea and vomiting.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
Blurred vision
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Works well to treat symptoms of motion sickness and vertigo
Available as chewable tablets and oral pills
Available as a lower-cost generics
Effects can last for a full day
Can make you sleepy or dizzy
Not available as a liquid form
Not approved for use in children less than 12 years old (especially Antivert, which isn't approved for use in children younger than 18 years of age)
Not the best choice for people over 65 years old, people with glaucoma, or people with problems urinating
If you have the chewable tablet, make sure to chew the tablet completely before swallowing. Don't swallow them whole.
If you're taking the regular tablets, swallow the tablet whole.
Meclizine can be taken with or without food. If it's upsetting your stomach, try taking it with food to help.
Meclizine can interact with a lot of medications, especially those that are anticholinergic or those that can cause sleepiness. Tell your provider or pharmacist about all the medications you're taking to make sure meclizine is safe for you. Don't start any new medications while taking meclizine without talking to your provider or pharmacist first. Doing so can raise your risk of overdose and severe side effects, including seizures, hallucinations (seeing things that aren't real), or even death.
Meclizine can make you sleepy and dizzy. Don't drive, operate machinery, or do anything that requires concentration until you know how this medication affects you. Avoid alcohol while taking meclizine. In addition, let you provider know if you're taking medications such as benzodiazepines, anxiety medications, or sleep medications, because all of these can make sleepiness and confusion from meclizine worse.
Don't use other antihistamines while taking meclizine without talking to your provider or pharmacist first. Doing so can raise your risk of taking too much medication (overdose). This can lead to side effects such as agitation, dry mouth, and behavior changes. Sometimes, side effects can be life-threatening.
Talk to your veterinarian before you give your dog any human medication to ease motion sickness.
Meclizine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Drinking alcohol while taking meclizine | Taking other medications that cause sleepiness | Age 65 and older
Meclizine can make you very sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you are over 65 years old, drink alcohol while taking this medication, or take other medications that cause sleepiness (e.g., benzodiazepines, anxiety medications, muscle relaxants, or sleep medications). Don't drive or operate machinery until you know how this medication affects you.
Risk factors: Asthma | Glaucoma | Trouble urinating
Ask your healthcare provider if it's ok for you to take meclizine if you have asthma, glaucoma, or an enlarged prostate gland. Taking meclizine can worsen your condition(s) and lead to more breathing problems, vision problems, or trouble urinating, respectively. Make sure your provider knows about all medical conditions you have or have had in the past before you start meclizine.
Motion sickness (OTC meclizine):
Adults and children age 12 years and older: The typical dose is 25 mg to 50 mg by mouth (or chewed for chewable tablets) once daily. Take it 1 hour before you travel or an activity that can cause motion sickness.
Children age less than 12 years: Ask your child's provider.
Vertigo (Prescription meclizine):
Adults and children age 12 years and older (except Antivert, which is used in adults only): The typical dose is 25 mg to 100 mg total per day, split into multiple doses and taken by mouth (or chewed for chewable tablets) throughout the day.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Over-the-counter (OTC) meclizine: Nausea, vomiting, or dizziness from motion sickness
Prescription meclizine: Vertigo (feeling like your surroundings are moving or spinning)
Prevention and treatment of nausea, vomiting, or dizziness from motion sickness
Prevention of nausea and vomiting due to:
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Amneal Pharmaceuticals. (2023). MECLIZINE HYDROCHLORIDE- meclizine tablet MECLIZINE HYDROCHLORIDE tablet [package insert]. DailyMed.
Borowy, C. S., et al. (2023). Antihistamine toxicity. StatPearls.
Casper Pharma. (2022). ANTIVERT- meclizine hcl tablet ANTIVERT- meclizine hcl tablet ANTIVERT- meclizine hcl tablet, chewable [package insert]. DailyMed.
Dramamine. (n.d.). Dramamine® Original Formula.
Dramamine. (n.d.). Dramamine All Day Less Drowsy.
Drugs and Lactation Database (LActMed). (2021). Meclizine.
Houston, B. T., et al. (2022). Meclizine. StatPearls.
Medtech products. (2022). DRAMAMINE LESS DROWSY- meclizine hydrochloride tablet [package insert]. DailyMed.
Mother to Baby | Fact Sheets. (2021). Meclizine. Organization of Teratology Information Specialists (OTIS).
National Eye Institute. (2022). Glaucoma.
Patel, P. N., et al. (2011). Meclizine: Safety and efficacy in the treatment and prevention of motion sickness. Clinical Medicine Insights: Therapeutics.
Patel, R. H., et al. (2022). Biochemistry, histamine. StatPearls.
Reliable 1 Laboratories. (2023). MECLIZINE HCL 12.5 MG tablet [package insert]. DailyMed.
Wang, Z., et al. (20012). Meclizine metabolism and pharmacokinetics: formulation on its absorption. Journal of Clinical Pharmacology.
WellSpring Pharmaceutical Corporation. (2021). BONINE- meclizine hydrochloride tablet, chewable [package insert]. DailyMed.
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