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Compare Barhemsys vs. Zofran

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Barhemsys (amisulpride)
Ondansetron (Zofran)
Barhemsys (amisulpride)
Ondansetron (Zofran)

Summary of Barhemsys vs. Zofran

Summary for Dopamine antagonist
Prescription only

Barhemsys (amisulpride) is an injectable medication used to prevent and treat nausea and vomiting after surgery. It's typically given by a healthcare provider through the vein, and doesn't have many common side effects.

Summary for Antiemetic
Prescription only

Ondansetron (Zofran) is an antiemetic (or anti-nausea) medication. It's used to prevent nausea and vomiting after surgery or cancer treatments. It works by stopping a chemical called serotonin from binding to receptors in the brain that cause the feeling of nausea and vomiting. Ondansetron (Zofran) is taken by mouth, typically every 8 to 12 hours. It comes in different formulations, including orally disintegrating tablet (ODT) and oral solution. It can also be given as injection by a healthcare professional (HCP) in a hospital setting. Side effects of this medication include headache, tiredness, and constipation or diarrhea.

Indications of Barhemsys vs. Zofran

Indications for
Indications for
•Prevention of nausea and vomiting due to cancer medications (chemotherapy) or radiation therapy
•Prevention of nausea and vomiting after surgery

Pros and Cons of Barhemsys vs. Zofran

Pros and Const for Dopamine antagonist
Pros
Cons
Pros and Const for Antiemetic
Pros
•Can use for both adults and children
•Available as a lower-cost generic
•Available as a liquid, dissolvable tablet, and injection for people who have problems swallowing pills or are too nauseous to keep medication down
•Possible option during pregnancy and breastfeeding
Cons
•Needs to be taken multiple times daily
•Might cause headache
•Can interact with certain medications, like antidepressants and migraine medications
•Not the best option for people who are at risk for stomach or gut blockages (bowel problems)

Common Side Effects of Barhemsys vs. Zofran

Common Side Effects for
Common Side Effects for
•Headache (up to 24%)
•Fatigue (up to 13%)
•Constipation (up to 9%)
•Diarrhea (up to 6%)

Warnings of Barhemsys vs. Zofran

Common Side Effects for
Common Side Effects for
•Severe allergic reactions
•Life-threatening abnormal heart rhythm (QT prolongation)
•Serotonin syndrome
•Risk of heart attack
•Masking of gut blockage and stomach bloating
•Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

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