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Compare Sustol vs. Reglan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sustol (granisetron)
    Metoclopramide (Reglan)
  • Sustol (granisetron)
    Metoclopramide (Reglan)

  • Summary of Sustol vs. Reglan

    Summary for Antiemetic
    Prescription only

    Sustol (granisetron) is a medication used to prevent nausea and vomiting due to cancer medications (chemotherapy) in adults. It can last for up to 7 days.

    Summary for Dopamine antagonist
    Prescription only

    Metoclopramide (Reglan) is FDA-approved to treat gastroesophageal reflux disease (GERD), as well as gastroparesis in people with diabetes. Providers might also prescribe it off-label for morning sickness during pregnancy and nausea and vomiting caused by chemotherapy. But metoclopramide (Reglan) isn’t a first-choice medication for these conditions because it has a black box warning for a serious side effect called tardive dyskinesia. Metoclopramide (Reglan) can interact with some commonly prescribed medications, such as risperidone (Risperdal) and quetiapine (Seroquel).

  • Indications of Sustol vs. Reglan

    Indications for
    •Prevention of nausea and vomiting caused by chemotherapy
    Indications for
    •Delayed stomach-emptying caused by diabetes (diabetic gastroparesis)
    •Severe acid reflux (gastroesophageal reflux disease or GERD) when other medications haven’t worked

  • Pros and Cons of Sustol vs. Reglan

    Pros and Const for Antiemetic
    Pros
    •Works well for preventing nausea
    •Lasts for up to 7 days
    •Good option for people who have a hard time taking pills
    Cons
    •Must be given by a healthcare provider as an injection under the skin
    •Not clear how safe the medication is in pregnant or breastfeeding females
    •Can't be used in children
    Pros and Const for Dopamine antagonist
    Pros
    •Available as a lower-cost generic medication
    •Available in many forms including tablet, fast-melting tablet, liquid, nasal spray, and injection
    •Typically starts to work in 30 minutes to 1 hour
    •A possible option during pregnancy
    Cons
    •Shouldn’t be used in children or for more than 12 weeks because of a higher risk of serious side effects
    •Needs to be taken multiple times a day
    •Interacts with a lot of medications such as antipsychotics, antidepressants, and opioids
    •Can't be used if you have Parkinson's disease, seizures, or stomach blockages or bleeds

  • Common Side Effects of Sustol vs. Reglan

    Common Side Effects for
    •Injection site reactions, such as bruising, redness, or swelling (37-62%)
    •Constipation (14-22%)
    •Weakness or lack of energy (11-21%)
    •Headache (9-13%)
    •Diarrhea (8-9%)
    •Stomach pain (7%)
    Common Side Effects for
    •Restlessness (10%)
    •Drowsiness (10%)
    •Lack of energy (10%)
    •Tiredness (10%)

  • Warnings of Sustol vs. Reglan

    Common Side Effects for
    •Injection site reactions
    •Serotonin syndrome
    •Severe allergic reactions
    •Stomach problems
    Common Side Effects for
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Other conditions with uncontrolled muscle movements (dystonia, Parkinsonian symptoms, and restlessness)
    •Neuroleptic malignant syndrome (NMS)
    •Depression and suicidal thoughts and behavior
    •High blood pressure
    •Swelling in arms, legs, or around the belly
    •High prolactin levels

  • Prices with our coupons for Sustol vs. Reglan

    Learn more about Sustol
    Learn more about Metoclopramide

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