Key takeaways
Sustol (granisetron) and Reglan (metoclopramide) are both used to treat nausea and vomiting, but they have some important differences. Sustol is an antiemetic that works by blocking serotonin, while Reglan is a dopamine antagonist that speeds up gut movements. Sustol is given as an injection by a healthcare provider and lasts up to 7 days, whereas Reglan is taken by mouth multiple times a day. Sustol is only available as a branded medication, while Reglan comes as a lower-cost generic. Common side effects of Sustol include injection site reactions and constipation, while Reglan can cause drowsiness and restlessness. Sustol can interact with medications that increase serotonin levels and increase the risk of serotonin syndrome, while Reglan can increase the risk for tardive dyskinesia, a serious movement disorder.
