Key takeaways
Methylprednisolone (Medrol) and dexamethasone are both corticosteroids used to treat various inflammatory and immune-related conditions. Methylprednisolone is available as oral tablets and injections, while dexamethasone comes in oral tablets, oral solutions, and injections. Dexamethasone is a long-acting corticosteroid, meaning its effects last longer than methylprednisolone. The typical starting oral dose for methylprednisolone ranges from 4 mg to 48 mg per day, whereas dexamethasone's starting dose ranges from 0.75 mg to 9 mg per day for adults. Both medications can cause side effects like weight gain, high blood sugar, and weakened bones with long-term use, but dexamethasone is considered stronger and has a higher risk of causing trouble sleeping and headaches. Additionally, both medications require careful management to avoid withdrawal symptoms if stopped suddenly.
