Key takeaways
Methylprednisolone (Medrol) and hydrocortisone (Cortef) are both corticosteroids used to treat conditions involving an overactive immune system, but they have some differences. Both medications are available as both oral tablets and injections, while hydrocortisone is available as oral tablets and a separate injection form called Solu-Cortef. Methylprednisolone is a stronger corticosteroid compared to hydrocortisone, which is considered a low-strength corticosteroid. Both medications can cause similar side effects like high blood sugar, high blood pressure, and mood changes. Methylprednisolone is available in a dose pack to help you organize your doses, while hydrocortisone does not have this feature. Both medications should be taken with food to avoid stomach upset and in the morning to prevent trouble sleeping.
