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Compare Medrol vs. Provigil

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Methylprednisolone (Medrol)
    Modafinil (Provigil)
  • Methylprednisolone (Medrol)
    Modafinil (Provigil)

  • Summary of Medrol vs. Provigil

    Summary for Corticosteroid
    Prescription only

    Methylprednisolone (Medrol) is a steroid medication used to treat different medical conditions with an overactive immune system. It's typically available by prescription as tablets. And it sometimes comes in a dose pack, which helps you organize the tablets into specific days and times. If you use methylprednisolone (Medrol) for a long time, it might cause certain side effects, such as weight gain, skin thinning, and high blood sugar.

    Summary for Wakefulness-promoting agent
    Prescription only

    Modafinil (Provigil) is a prescription medication used to improve wakefulness in people who have extreme sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. It's considered a controlled substance since this medication has a potential to cause misuse. You should avoid alcohol while taking modafinil (Provigil), as well as certain other medications to avoid any serious interactions and side effects. Common side effects of modafinil (Provigil), however, include headache and nausea.

  • Indications of Medrol vs. Provigil

    Indications for

    Methylprednisolone (Medrol) is used for many different medical conditions, including:

    •Conditions affecting certain hormones (e.g., low adrenal hormones)
    •Joint conditions (e.g., rheumatoid arthritis)
    •Lupus
    •Skin conditions (e.g., Stevens-Johnson syndrome)
    •Allergic reactions
    •Eye inflammation
    •Lung problems
    •Conditions related to blood cells
    •Cancer of blood cells (e.g., leukemia)
    •Gut conditions (e.g., ulcerative colitis)
    •Multiple sclerosis
    Indications for
    •Excessive sleepiness due to narcolepsy, shift work disorder, or obstructive sleep apnea

  • Pros and Cons of Medrol vs. Provigil

    Pros and Const for Corticosteroid
    Pros
    •Available as a lower-cost, generic medication
    •Works well to treat many different conditions involving the immune system
    •Also available in an easy-to-follow dose pack that organizes tablets into specific days and times
    Cons
    •Long-term use might weaken your bones and cause high blood sugar
    •Can cause side effects like upset stomach, mood changes, and sleep problems
    •Need to slowly lower your dose if you take it for a long time
    Pros and Const for Wakefulness-promoting agent
    Pros
    •Convenient once-daily dosing
    •Can help you feel awake without feeling overstimulated
    •Available as a lower-cost generic
    •Doesn't usually interfere with falling asleep when taken as recommended
    •Can help with attention as well as fatigue
    Cons
    •Interacts with many medications, including hormonal birth controls, warfarin (Coumadin), and omeprazole (Prilosec)
    •Older adults and people with severe liver problems might need a lower dose
    •Not known whether it's safe or works well for children
    •Generally not recommended if you're pregnant or breastfeeding

  • Common Side Effects of Medrol vs. Provigil

    Common Side Effects for
    •Swelling
    •Muscle weakness
    •Stomach pain
    •Bloating
    •Increased appetite
    •Trouble sleeping
    •Weight gain
    •Dizziness
    Common Side Effects for
    •Headache (34%)
    •Nausea (11%)
    •Feeling nervous (7%)
    •Runny nose (7%)
    •Back Pain (6%)
    •Diarrhea (6%)
    •Anxiety (5%)
    •Dizziness (5%)
    •Upset stomach and indigestion (5%)
    •Trouble sleeping (5%)

  • Warnings of Medrol vs. Provigil

    Common Side Effects for
    •New or worsened infection
    •Mood and behavior changes
    •Reduced adrenal gland function
    •Changes in heart and kidney function
    •Stomach problems
    •Bone problems with long-term use
    •Eye problems with long-term use
    •High blood sugar
    Common Side Effects for
    •Serious allergic reactions
    •Serious skin reactions
    •Driving impairment
    •Heart problems
    •Mental health disorder symptoms

  • Prices with our coupons for Medrol vs. Provigil

    Learn more about Methylprednisolone
    Learn more about Modafinil

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