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Difluprednate vs. Dexamethasone

Difluprednate 0.05% eye drops, also known by its brand name Durezol, is a prescription corticosteroid that's used to treat eye inflammation. It's approved for adults and children who've just had eye surgery or who have anterior uveitis. The drops are placed directly in the eye(s) 4 times per day for at least 2 weeks. After this time, your prescriber will slowly lower your dose until it's safe to stop the medication altogether. Typical side effects include swelling in the front of the eye and light sensitivity. Difluprednate (Durezol) is available as a generic.

• Eye inflammation and pain from eye surgery
• Endogenous anterior uveitis

• Eye swelling (up to 15%)
• Eye redness (up to 15%)
• Eye pain (up to 15%)
• Eye sensitivity to light (up to 15%)

• For use in the eye only
• Possible eye infections and eye problems when used for a long time
• Slow healing of the eye after an eye procedure
• Damage to contact lenses

Dexamethasone is a corticosteroid that's used to treat many inflammatory conditions, including allergic reactions and certain autoimmune conditions. If you've been taking dexamethasone for a long time, you're at higher risk for side effects like weight gain and weakened bones. Dexamethasone also has many drug interactions, so make sure to tell your provider and pharmacist what medications you're taking before starting this steroid. This medication is available as oral tablets and solutions, as well as an injection that's usually given in a healthcare setting.

• Allergies and allergic reactions
• Skin conditions
• Hormone-related conditions
• Eye conditions
• Stomach conditions
• Respiratory disorders
• Autoimmune and rheumatic conditions
• Multiple myeloma (Hemady brand only), blood cancers, and other blood-related conditions
• Certain eye conditions
• Nervous system and brain conditions
• Kidney diseases
• Shock

• Difficulty sleeping
• Higher blood sugar levels
• Headache
• Mood swings
• Nausea
• Stomach pain
• Feeling more hungry
• Weight gain

• Lowered stress hormone levels
• Higher risk of infections
• High blood pressure and kidney-related problems
• Stomach and intestinal problems
• Weakened bones
• Eye problems