Key takeaways
Methylprednisolone (Medrol) and prednisolone sodium phosphate (Pediapred) are both corticosteroids used to treat conditions related to an overactive immune system or inflammation, such as rheumatoid arthritis and lupus. They work by reducing inflammation and calming the immune response. However, there are some differences between the two medications. Methylprednisolone is available in both oral and injectable forms, while prednisolone is only available as an oral solution or tablet. The typical starting dose for methylprednisolone ranges from 4 mg to 48 mg per day, whereas prednisolone's starting dose ranges from 5 mg to 60 mg per day. Both medications are available as a lower-cost generic. Common side effects for both include trouble sleeping, mood changes, and stomach pain, and can also cause high blood sugar with long-term use. Both medications have a number of interactions, so be sure your prescriber and pharmacist have a complete list of your medications.
