Key takeaways
Testosterone topical gel (Testim, AndroGel, Fortesta, Vogelxo) and testosterone cypionate (Depo-Testosterone) are both testosterone replacement medications used to treat low testosterone (hypogonadism) in adult males. They belong to the same drug class and work by adding or replacing testosterone in the body. However, they differ in their form and administration. Testosterone gel is applied topically to the skin once a day, while testosterone cypionate is injected into the buttock muscle every 2 to 4 weeks. Testosterone gel can accidentially expose others to the medication through skin-to-skin contact, which can cause unwanted side effects in those exposed, while the injection does not have this risk. Testosterone gel is available in various brand names and some generics, whereas testosterone cypionate is available as a lower-cost generic. Common side effects of the gel include skin irritation and acne, while the injection may cause acne, pain at the injection site, and enlargement of male breasts. Both medications carry risks of serious side effects like heart attack and stroke, especially if misused.
