Key takeaways
Testosterone gel (Testim, AndroGel, Fortesta, Vogelxo) and Testopel (testosterone pellets) are both testosterone replacement therapies used to treat low testosterone (hypogonadism) in males. However, they differ in their forms and administration. Testopel is also used for delayed puberty. Testosterone gel is applied topically to the skin once a day, while Testopel is an implantable pellet placed under the skin by a healthcare professional every 3 to 6 months. Testosterone gel is available in various brand names and some generics, whereas Testopel is only available as a brand-name medication. Testosterone gel can accidentially expose others to the medication through skin-to-skin contact, which can cause unwanted side effects in those exposed. This is not a concern with Testopel. Common side effects of the gel include skin irritation and acne, while Testopel may cause acne, pain and swelling at the implantation site, and enlargement of male breasts. Both medications can interact with blood thinners like warfarin, increasing the risk of bleeding.
