Key takeaways
Scopolamine (Transderm Scop) and Palonosetron (Aloxi) are both used to prevent nausea and vomiting, but they work in different ways and are used for different situations. Scopolamine is an anticholinergic that comes as a patch you place behind your ear, and it's mainly used to prevent motion sickness and nausea from surgery. You need to apply it at least 4 hours before you need it, and it can last up to 3 days. Common side effects include dry mouth, dizziness, and sleepiness. On the other hand, Palonosetron is a serotonin antagonist given as an IV injection by a healthcare provider, and it's used to prevent nausea and vomiting from chemotherapy and surgery. It works quickly and can last up to 5 days. Common side effects are headache and constipation. Scopolamine is available as a generic. Palonosetron's brand name Aloxi is discontinued, but the generic form is still available.
