Ziac vs. Dutoprol for Hypertension: Important Differences and Potential Risks.

Key takeaways

Ziac (bisoprolol/hydrochlorothiazide) and Dutoprol (metoprolol succinate/hydrochlorothiazide) are combination medications used to treat high blood pressure. They each contain a beta blocker and a diuretic, which work together to lower blood pressure. However, there are several differences between them. Ziac combines bisoprolol, a beta blocker, with hydrochlorothiazide, a diuretic, and is available as a prescription medication taken once daily. Dutoprol, on the other hand, combined metoprolol succinate, another beta blocker, with hydrochlorothiazide, but has been discontinued and is no longer available. Both medications share common side effects like dizziness and tiredness. Ziac comes in fixed dosage strengths, which can make it harder to adjust the dosages of the individual ingredients. While Dutoprol is not available, the medications it contained can be prescribed separately.

Ziac

(bisoprolol / hydrochlorothiazide)

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Dutoprol

(metoprolol succinate / hydrochlorothiazide)

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Summary for Ziac

Prescription only

Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

Indications for Ziac

High blood pressure

Pros and Cons for Ziac

Pros

Only taken once daily
Combines two blood pressure medications into one tablet
Can take with or without food

Cons

Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
Can make you urinate more often
Not a good option for people with a sulfa allergy

Common Side Effects for Ziac

Dizziness (5%)
Tiredness (5%)
Headache (5%)
Diarrhea (4%)

Warnings for Ziac

Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
Risk of heart failure
Changes in fluids and electrolytes in the body
Hidden symptoms of low blood sugar
Hidden symptoms of overactive thyroid
Caution use in people with breathing problems
Caution use in people with peripheral artery disease (PAD)
Risk of vision problems and glaucoma

Summary for Dutoprol

Discontinued

Dutoprol (metoprolol succinate / hydrochlorothiazide) is a combination medication used to control blood pressure to lower the risk of a heart attack or stroke. This medication has been discontinued by the manufacturer and is no longer available in the United States.