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Zeposia vs. Entyvio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zeposia (ozanimod) and Entyvio (vedolizumab) are both medications used to treat ulcerative colitis (UC) in adults. However, they belong to different medication classes and have distinct uses and administration methods. Zeposia is a sphingosine 1-phosphate receptor modulator also approved for relapsing forms of multiple sclerosis (MS), while Entyvio is an integrin antagonist also used for Crohn's disease (CD). Zeposia is taken orally once daily, whereas Entyvio is administered either as an intravenous infusion every two months or as a subcutaneous injection every two weeks. Common side effects of Zeposia include infections and changes in liver tests, while Entyvio may cause headaches, mild infections, and joint pain. You should avoid foods high in tyramine (e.g., aged cheeses, pickled or fermented foods, or alcohol) while taking Zeposia.

Zeposia

(ozanimod)

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Entyvio

(vedolizumab)

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Summary for Zeposia

Prescription only

Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.

Indications for Zeposia

Pros and Cons for Zeposia

Pros

  • Taken by mouth, with or without food
  • Taken once a day
  • Starter pack available to help guide dosing at the beginning of treatment

Cons

  • Might raise your risk of infections
  • Not safe for people with certain heart problems or severe liver problems
  • Not approved for children

Common Side Effects for Zeposia

Warnings for Zeposia

  • Risk of infections
  • Risk of brain infection (progressive multifocal leukoencephalopathy)
  • Slow heart rate and heart rhythm
  • Higher blood pressure
  • Liver damage
  • Breathing problems
  • Eye problem called macular edema
  • Brain problem called posterior reversible encephalopathy syndrome (PRES)
  • Possible risk of skin cancer
  • Harm to an unborn baby

Summary for Entyvio

Prescription only

Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

Indications for Entyvio

Pros and Cons for Entyvio

Pros

  • Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
  • Comes as prefilled syringes and pens for injections under the skin that can be given at home

Cons

  • IV infusions can only be given by a healthcare professional at a medical office
  • Can raise your risk of serious side effects, like infusion reactions and infections

Common Side Effects for Entyvio

Warnings for Entyvio

  • Infusion-related reactions and allergic reactions
  • Risk of serious infections
  • Risk of brain infection (progressive multifocal leukoencephalopathy)
  • Liver problems

Prices with our coupons for Zeposia vs. Entyvio

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Zeposia30 capsules / 0.92mg of
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Entyvio2 cartons / prefilled pen of 108mg/0.68ml
$6,993.40$9,743.21
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