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Trulicity vs. Saxenda

Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

• Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
• Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors

• Nausea (12-21%)
• Diarrhea (7-13%)
• Vomiting (6-13%)
• Stomach pain (7-9%)
• Low appetite (5-9%)
• Fatigue (4-6%)
• Indigestion (3-6%)

• Thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Low blood sugar when used with certain diabetes medications
• Severe allergic reactions
• Kidney damage
• Severe stomach-related side effects
• Worsening eye problems in people with diabetic retinopathy
• Gallbladder problems
• Breathing fluid into your lungs during anesthesia or deep sedation

Saxenda (generic name liraglutide) is a once-daily injection given under the skin that's used for weight loss. It's approved for certain adults and children ages 12 years and up. And it works best when used along with a balanced diet and exercise. This prescription weight loss medication is a glucagon-like peptide-1 (GLP-1) agonist. It works by slowing down your gut and making you feel less hungry. Saxenda (liraglutide) comes as a prefilled pen you use to inject your dose. Some common side effects include nausea, vomiting, and diarrhea.

• Weight loss and long-term weight management in:
  • People ages 12 years and older with a body weight greater than 132 lbs and obesity
  • Adults who are considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

Adults:

• Nausea (39%)
• Diarrhea (21%)
• Constipation (19%)
• Vomiting (16%)
• Injection site reaction (e.g., redness, itching, rash; 14%)
• Headache (14%)
• Low blood sugar in people with Type 2 diabetes (13%)
• Indigestion (10%)

Children 12 years and up:

• Nausea (42%)
• Vomiting (34%)
• Diarrhea (22%)
• Low blood sugar (15%)
• Stomach inflammation (13%)
• Dizziness (10%)

• Possible risk for thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Faster heart rate
• Severe stomach side effects
• Kidney problems due to dehydration
• Allergic reactions
• Lung problems during anesthesia or deep sedation