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Trulance vs. Linzess

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Trulance

(plecanatide)

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Linzess

(linaclotide)

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Summary for Trulance

Prescription only

Trulance (plecanatide) is used to treat adults with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (long-term constipation of an unknown cause). It belongs to a group of medications called guanylate cyclase-C (GC-C) agonists. The usual dosage is 1 tablet by mouth once a day. A possible side effect of the medication is diarrhea. This medication isn't available as a generic, but you can get it as the brand name Trulance.

Indications for Trulance

Pros and Cons for Trulance

Pros

  • Can take at any time of the day with or without food
  • Only need to take once a day
  • Might start to see overall improvement after a week of taking the medication every day

Cons

  • Doesn’t provide immediate relief from constipation like laxatives do
  • Not a good option for people with a gut blockage
  • Not safe for children younger than 18 years of age

Common Side Effects for Trulance

  • Diarrhea (up to 5%)

Warnings for Trulance

  • Serious dehydration in children younger than 6 years of age
  • Severe diarrhea

Summary for Linzess

Prescription only

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

Indications for Linzess

Pros and Cons for Linzess

Pros

  • Only need to take once a day
  • Can start to see improvement as early as a week of taking it every day

Cons

  • Must take on an empty stomach (30 minutes before a meal)
  • Can cause diarrhea

Common Side Effects for Linzess

Adults:

  • Diarrhea
  • Stomach pain
  • Having gas
  • Bloating and feeling full in the belly

Children:

  • Diarrhea

Warnings for Linzess

  • Not for children under 2 years old because of risk of serious dehydration
  • Severe diarrhea

Prices with our coupons for Trulance vs. Linzess

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Trulance1 dose pack / 30 tablets of 3mg
$605.11$780.51
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Price Card Drug Icon
Linzess30 capsules / 145mcg
$285.50$730.99
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