Trulance vs. Linzess for Constipation: Important Differences and Potential Risks.

Trulance

(plecanatide)

Linzess

(linaclotide)

Summary for Trulance

Prescription only

Trulance (plecanatide) is used to treat adults with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (long-term constipation of an unknown cause). It belongs to a group of medications called guanylate cyclase-C (GC-C) agonists. The usual dosage is 1 tablet by mouth once a day. A possible side effect of the medication is diarrhea. This medication isn't available as a generic, but you can get it as the brand name Trulance.

Indications for Trulance

Irritable bowel syndrome with constipation (IBS-C)
Chronic idiopathic constipation (CIC)

Pros and Cons for Trulance

Pros

Can take at any time of the day with or without food
Only need to take once a day
Might start to see overall improvement after a week of taking the medication every day

Cons

Doesn’t provide immediate relief from constipation like laxatives do
Not a good option for people with a gut blockage
Not safe for children younger than 18 years of age

Common Side Effects for Trulance

Diarrhea (up to 5%)

Warnings for Trulance

Serious dehydration in children younger than 6 years of age
Severe diarrhea

Summary for Linzess

Prescription only

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

Indications for Linzess

Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
Chronic idiopathic constipation (CIC) in adults
Functional constipation (FC) in children 2 years and older

Pros and Cons for Linzess

Pros

Only need to take once a day
Can start to see improvement as early as a week of taking it every day

Cons

Must take on an empty stomach (30 minutes before a meal)
Can cause diarrhea

Common Side Effects for Linzess

Adults:

Diarrhea
Stomach pain
Having gas
Bloating and feeling full in the belly

Children:

Diarrhea

Warnings for Linzess

Not for children under 2 years old because of risk of serious dehydration
Severe diarrhea

Prices with our coupons for Trulance vs. Linzess

Trulance1 dose pack / 30 tablets of 3mg

$605.11$780.51

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Linzess30 capsules / 145mcg

$286.68$384.24

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Trulance vs. Linzess

Trulance

Linzess

Summary for Trulance

Indications for Trulance

Pros and Cons for Trulance

Pros

Cons

Common Side Effects for Trulance

Warnings for Trulance

Summary for Linzess

Indications for Linzess

Pros and Cons for Linzess

Pros

Cons

Common Side Effects for Linzess

Warnings for Linzess

Prices with our coupons for Trulance vs. Linzess

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Trulance

Linzess

Summary for Trulance

Indications for Trulance

Pros and Cons for Trulance

Pros

Cons

Common Side Effects for Trulance

Warnings for Trulance

Summary for Linzess

Indications for Linzess

Pros and Cons for Linzess

Pros

Cons

Common Side Effects for Linzess

Warnings for Linzess