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Trulance vs. Linzess

Trulance (plecanatide) is used to treat adults with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (long-term constipation of an unknown cause). It belongs to a group of medications called guanylate cyclase-C (GC-C) agonists. The usual dosage is 1 tablet by mouth once a day. A possible side effect of the medication is diarrhea. This medication isn't available as a generic, but you can get it as the brand name Trulance.

• Irritable bowel syndrome with constipation (IBS-C)
• Chronic idiopathic constipation (CIC)

• Diarrhea (up to 5%)

• Serious dehydration in children younger than 6 years of age
• Severe diarrhea

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

• Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
• Chronic idiopathic constipation (CIC) in adults
• Functional constipation (FC) in children 2 years and older

Adults:

• Diarrhea
• Stomach pain
• Having gas
• Bloating and feeling full in the belly

Children:

• Diarrhea

• Not for children under 2 years old because of risk of serious dehydration
• Severe diarrhea