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Tenoretic vs. Ziac

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tenoretic (atenolol/chlorthalidone) and Ziac (bisoprolol/hydrochlorothiazide) are both combination medications used to treat high blood pressure, but they have some differences. Tenoretic combines atenolol, a cardioselective beta blocker, with chlorthalidone, a thiazide-like diuretic, while Ziac combines bisoprolol, another cardioselective beta blocker, with hydrochlorothiazide, a thiazide diuretic. Both medications are taken once daily and can cause side effects like dizziness and nausea. However, Tenoretic is not recommended for use during pregnancy or breastfeeding, while Ziac hasn't been well-studied in human pregnancies but is suggested to be harmful based on animal studies. Both medications can make your skin more sensitive to sunlight, whereas Ziac can cause vision problems and glaucoma in rare cases. Both medications come in fixed doses, making it harder to adjust the individual components.

Tenoretic

(atenolol / chlorthalidone)

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Ziac

(bisoprolol / hydrochlorothiazide)

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Summary for Tenoretic

Prescription only

Tenoretic (atenolol / chlorthalidone) is used to lower blood pressure in adults. It's a combination of two types of blood pressure medications: a beta blocker (atenolol) and a diuretic (chlorthalidone). The tablet is taken by mouth once daily. Side effects, like dizziness and tiredness, are usually mild and they get better over time. Tenoretic (atenolol / chlorthalidone) is available as a brand-name and generic medication.

Indications for Tenoretic

Pros and Cons for Tenoretic

Pros

  • Combines two medications into one pill to help lower blood pressure better
  • Only need to take once a day
  • Can take with or without food
  • Gets rid of extra fluids in your body

Cons

  • Might make you urinate more often
  • Comes in fixed doses, which makes it hard to adjust the dose if needed
  • Not safe if you're pregnant or breastfeeding
  • Might cause an allergic reaction if you have a sulfa allergy

Common Side Effects for Tenoretic

Atenolol:

  • Dizziness
  • Tiredness
  • Nausea
  • Slow heartbeat

Chlorthalidone:

  • Dizziness when standing up too quickly
  • Stomach irritation or cramps
  • Nausea
  • Constipation

Warnings for Tenoretic

  • Risk of heart problems after stopping Tenoretic (atenolol / chlorthalidone) suddenly
  • Risk of heart failure
  • Risk of heart block when taken with calcium channel blockers
  • Caution use in people with breathing problems
  • Kidney problems
  • Changes in fluids and electrolytes in the body
  • Hidden symptoms of low blood sugar
  • Hidden symptoms of overactive thyroid
  • Possible gout
  • Risk of harm to baby

Summary for Ziac

Prescription only

Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

Indications for Ziac

Pros and Cons for Ziac

Pros

  • Only taken once daily
  • Combines two blood pressure medications into one tablet
  • Can take with or without food

Cons

  • Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
  • Can make you urinate more often
  • Not a good option for people with a sulfa allergy

Common Side Effects for Ziac

  • Dizziness (5%)
  • Tiredness (5%)
  • Headache (5%)
  • Diarrhea (4%)

Warnings for Ziac

  • Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
  • Risk of heart failure
  • Changes in fluids and electrolytes in the body
  • Hidden symptoms of low blood sugar
  • Hidden symptoms of overactive thyroid
  • Caution use in people with breathing problems
  • Caution use in people with peripheral artery disease (PAD)
  • Risk of vision problems and glaucoma

Prices with our coupons for Tenoretic vs. Ziac

Price Card Drug Icon
Atenolol/Chlorthalidone90 tablets / 50mg/25mg
$37.65$103.25
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Price Card Drug Icon
Bisoprolol/HCTZ90 tablets / 5mg/6.25mg
$33.21$121.00
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