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Soliqua 100/33 vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Soliqua 100/33 (insulin glargine/lixisenatide) and Ozempic (semaglutide) are both injectable medications used to treat Type 2 diabetes. They both contain glucagon-like peptide-1 (GLP-1) agonists, which help lower blood sugar levels. However, Soliqua 100/33 is a combination medication that also contains insulin glargine, a long-acting insulin. Soliqua 100/33 is injected once daily, whereas Ozempic is injected once weekly. Soliqua 100/33 must be taken within an hour before your first meal, while Ozempic can be taken at any time of the day, with or without food. Both medications can cause nausea and diarrhea and may increase your risk for some types of thyroid cancer.

Soliqua 100/33

 

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Ozempic

(semaglutide)

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Summary for Soliqua 100/33

Prescription only

Soliqua 100/33 is a combination medication for diabetes that contains insulin glargine (a long-acting insulin) and lixisenatide (a glucagon-like peptide-1 (GLP-1) receptor agonist). It helps manage blood sugar levels along with diet and exercise in adults with Type 2 diabetes. The medication comes as a prefilled pen and is injected under the skin once a day within 1 hour before you eat your first meal of the day. Soliqua 100/33 commonly causes stomach-related side effects like nausea and diarrhea.

Indications for Soliqua 100/33

Pros and Cons for Soliqua 100/33

Pros

  • Lowers A1C by about 1%
  • Conveniently combines two medications in one injection
  • Injected under the skin once a day

Cons

  • Risk of low blood sugar, especially if meals are skipped or delayed
  • Commonly causes stomach-related side effects like nausea and diarrhea
  • Must be taken within 1 hour before the first meal of the day

Common Side Effects for Soliqua 100/33

  • Nausea (10%)
  • Low blood sugar (8%)
  • Common cold-like symptoms (7%)
  • Diarrhea (7%)
  • Headache (5%)

Warnings for Soliqua 100/33

  • Severe allergic reactions
  • Inflammation of the pancreas (pancreatitis)
  • Risk of high and low blood sugar levels
  • Dangerously low blood sugar levels (hypoglycemia)
  • Kidney damage
  • Low blood potassium levels
  • Fluid buildup and heart failure with certain diabetes medications
  • Gallbladder problems
  • Aspiration during anesthesia or sedation

Summary for Ozempic

Prescription only

Ozempic (semaglutide) is a GLP-1 agonist used with diet and exercise to help adults manage Type 2 diabetes. It can also lower the risk of heart attack, stroke, and heart-related death in some people with Type 2 diabetes. It comes as a once-weekly injection under the skin and as a tablet taken by mouth once a day. The injection is also approved to help slow worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Common side effects include nausea, vomiting, and diarrhea.

Indications for Ozempic

Injection:

Tablets:

Pros and Cons for Ozempic

Pros

  • Only given once per week
  • Might help you lose weight
  • Helps lower the risk of heart problems and kidney problems in people with type 2 diabetes
  • Available as an injection and an oral tablet

Cons

  • Commonly causes nausea, vomiting, and diarrhea
  • Risk of low blood sugar if taken with certain diabetes medications
  • Can't be used for Type 1 diabetes
  • Interacts with medications taken by mouth

Common Side Effects for Ozempic

Note: Side effects listed above are for Ozempic (semaglutide) injection

Warnings for Ozempic

  • Risk of thyroid tumors
  • Inflammation of the pancreas (pancreatitis)
  • Eye problems
  • Low blood sugar (hypoglycemia) when taken with certain diabetes medications
  • Kidney damage
  • Severe stomach problems
  • Severe allergic reactions
  • Gallbladder problems
  • Lung problems during anesthesia or deep sedation

Prices with our coupons for Soliqua 100/33 vs. Ozempic

Price Card Drug Icon
Soliqua 100/331 carton / 5 solostar pens of 3ml
$901.41$1,051.93
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Price Card Drug Icon
Ozempic30 tablets / 1.5mg
$149.00$1,229.69
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