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Rinvoq vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Skyrizi (risankizumab) are both medications used to treat inflammatory conditions, such as psoriatic arthritis and Crohn's disease. However, they belong to different medication classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Skyrizi is an interleukin antagonist. Rinvoq is taken orally, either as an extended-release tablet or an oral solution, and is typically taken once daily. In contrast, Skyrizi is administered as an injection, with dosing every 2 or 3 months after initial doses. Common side effects of Rinvoq include a higher risk of infections, acne, and nausea, while Skyrizi may cause joint pain and upper respiratory infections. Both medications can weaken your immune system and raise the risk of infections, but they have some different interactions and precautions. For example, you should avoid grapefruit with Rinvoq, and Skyrizi requires careful handling and storage.

Rinvoq

(upadacitinib)

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Skyrizi

(risankizumab)

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Summary for Rinvoq

Prescription only

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

Indications for Rinvoq

Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

Pros and Cons for Rinvoq

Pros

  • Can treat many different inflammatory conditions
  • Available as a tablet and a liquid
  • The tablet only needs to be taken once a day

Cons

  • Can raise risk for infections
  • Not the best option for people with severe liver or kidney problems
  • Not safe for use during pregnancy

Common Side Effects for Rinvoq

Note: Side effects listed were reported by people who took Rinvoq for eczema.

Warnings for Rinvoq

  • Serious infections
  • Possible higher risk of death for people with rheumatoid arthritis
  • Risk of cancer
  • Possible risk of heart attack, stroke, and other blood clots
  • Severe allergic reaction
  • Stomach and gut tears
  • Abnormal lab results (e.g., blood cell counts, cholesterol levels)
  • Possible harm to unborn babies
  • Medication in stool

Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after a couple of starter doses (depends on your condition)
  • Can give injections under the skin at home after you get trained

Cons

  • Must be given as an injection
  • Not approved for children

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Prices with our coupons for Rinvoq vs. Skyrizi

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Rinvoq30 tablets / 15mg
$6,244.67$8,869.21
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Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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