Key takeaways
Methylprednisolone (Medrol) and Prednisone (Rayos, Prednisone Intensol) are both corticosteroids used to treat conditions related to an overactive immune system or inflammation. Methylprednisolone is available in both oral and injectable forms, while prednisone is only available in oral forms, including tablets and liquid. Both medications are available as lower-cost generics. Both medications can cause similar side effects like stomach irritation, mood changes, and sleep problems, but may also cause bone and eye problems with long-term use. To avoid sleep problems, it’s best to take the medications in the morning. The delayed-release form of prednisone (Rayos) may be taken before bed, as it releases the medication 4 hours after ingestion. Both medications require careful monitoring and should not be stopped abruptly to avoid withdrawal symptoms.
