Key takeaways
Itraconazole (Sporanox, Tolsura) and clotrimazole (Lotrimin AF) are both antifungal medications, but they have different uses and forms. Itraconazole is a prescription-only medication taken orally to treat serious fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. It needs to be taken with food and can interact with many other medications, potentially causing serious heart and liver problems. On the other hand, clotrimazole is an over-the-counter cream applied to the skin to treat common fungal infections like athlete's foot, jock itch, and ringworm. It is generally safe with few side effects, though it can cause mild skin irritation. While itraconazole is used for more severe infections and has significant risks, clotrimazole is used for less severe skin infections and is easier to obtain and use.
