Key takeaways
Ibsrela (tenapanor) and Viberzi (eluxadoline) are both prescription medications used to treat different types of irritable bowel syndrome (IBS). Ibsrela is used for IBS with constipation (IBS-C), while Viberzi is used for IBS with diarrhea (IBS-D). Ibsrela works by preventing sodium absorption in the gut, which helps soften stool and relieve constipation, and is taken twice daily before meals. On the other hand, Viberzi attaches to opioid receptors in the intestines to reduce abdominal pain and diarrhea and is also taken twice daily with food. Unlike Ibsrela, Viberzi is a controlled substance due to its potential for abuse and dependence. Common side effects of Ibsrela include diarrhea and bloating, whereas Viberzi can cause constipation and nausea. Additionally, Viberzi is not suitable for people without a gallbladder or those who consume more than three alcoholic drinks per day due to the risk of pancreatitis.
