Key takeaways
Hydrocortisone (Locoid, Pandel) and methylprednisolone (Medrol) are both corticosteroids used to treat conditions related to inflammation and an overactive immune system. However, they differ in their forms and specific uses. Hydrocortisone is a topical medication available over-the-counter and by prescription, used for skin conditions like eczema and psoriasis. It comes in creams, ointments, lotions, and solutions. Methylprednisolone, on the other hand, is an oral and injectable medication available only by prescription, used for a wider range of conditions, including joint issues, lupus, and allergic reactions. While hydrocortisone is applied directly to the skin, methylprednisolone is taken by mouth or injected, and it can affect the whole body. Side effects of hydrocortisone are mostly skin-related, like burning and itching, whereas methylprednisolone can cause systemic effects such as weight gain, mood changes, and high blood sugar. Both medications can lead to adrenal suppression if used long-term, but methylprednisolone requires careful monitoring for more serious systemic side effects.
