Key takeaways
Haldol (haloperidol) and Invega (paliperidone) are both antipsychotic medications used to treat schizophrenia, but they have some key differences. Haldol is a typical antipsychotic that works by blocking dopamine activity in the brain and is available in oral forms, as well as an injection, either long-acting or short-acting. In contrast, Invega is an atypical antipsychotic that affects both dopamine and serotonin levels and is taken orally as an extended-release tablet. Haldol long-acting injection is typically given monthly by a healthcare provider, and Invega is also available as a long-acting injection. Both medications can cause movement-related side effects, such as rigid muscles and tremors, as well as weight gain and high blood sugar levels. However, Haldol may be less likely to cause weight gain compared to Invega. Both medications should not be used in older adults with dementia-related psychosis due to an increased risk of death.
