Key takeaways
Fludrocortisone (generic name) and topical hydrocortisone (generic name) are both corticosteroids but are used for different purposes. Fludrocortisone is taken orally and is primarily used to treat conditions like Addison's disease and congenital adrenal hyperplasia by maintaining the balance of sodium, potassium, and water in your body. It is typically taken once daily and can cause side effects like high blood pressure and swelling. On the other hand, topical hydrocortisone is used topically to treat skin conditions such as eczema, psoriasis, and rashes. It comes in various forms like creams, ointments, and lotions, and can be found over-the-counter in lower strengths or by prescription in higher strengths. There are also oral and injectable forms used to treat other conditions. While fludrocortisone is only available as a generic, hydrocortisone is available both as a generic and under several brand names like Locoid and Pandel. Hydrocortisone is applied multiple times a day and can cause skin irritation and thinning if used for too long. Both medications require careful use to avoid withdrawal symptoms and other side effects.
