Key takeaways
Amphetamine sulfate (Evekeo, Adzenys XR ODT) and Methylphenidate ER (Concerta, Adhansia XR) are both stimulants used to treat attention deficit hyperactivity disorder (ADHD), but they have some differences. Amphetamine sulfate is also approved for narcolepsy and short-term obesity treatment, while Methylphenidate ER is only approved for ADHD. Amphetamine sulfate comes in various forms, including tablets, dissolvable tablets, and liquids, whereas Methylphenidate ER is available in tablets, capsules, chewable tablets, and liquids. Both medications can cause difficulty sleeping and loss of appetite, but Methylphenidate ER might also cause headaches and stomach pain. Amphetamine sulfate works by raising levels of norepinephrine, dopamine, and serotonin, while Methylphenidate ER primarily affects norepinephrine and dopamine. Both medications have a risk of misuse and dependence and are controlled substances. If you're pregnant or breastfeeding, it's important to discuss the risks and benefits of these medications with your provider.
