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Eucrisa vs. Clobex

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Eucrisa (crisaborole) and Clobetasol are both used to treat skin conditions, but they have some key differences. Eucrisa (crisaborole) is a PDE4 inhibitor used to treat mild-to-moderate eczema in people 3 months and older. It is only available as a brand medication and is applied as an ointment twice daily. Clobetasol, on the other hand, is a super potent corticosteroid used for more severe skin problems like psoriasis and eczema. It comes in various forms, including cream, shampoo, and spray, and is generally for short-term use due to potential serious side effects like skin thinning and high blood sugar. Clobetasol is available as a lower-cost generic medication and some formulations (solution and foam) can be used by children as young as 12 years old. While Eucrisa can be used safely in young children, Clobetasol is more potent and is used for more severe conditions but with more caution due to its stronger effects and potential risks.

Eucrisa

(crisaborole)

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Clobetasol

 

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Summary for Eucrisa

Prescription only

Eucrisa (crisaborole) is an ointment that's used to treat eczema for people 3 months and older. The medication is a phosphodiesterase 4 (PDE4) inhibitor that works to help reduce skin inflammation and itching from eczema. The ointment is usually applied to the affected area(s) of skin twice a day. The most common side effect is burning or stinging on the skin where you apply the medication.

Indications for Eucrisa

Pros and Cons for Eucrisa

Pros

  • Easy-to-apply ointment
  • Safe to use on children as young as 3 months old
  • Can start to see improvement in your skin in about 1 week
  • An alternative to topical steroids to treat eczema

Cons

  • Must use twice daily
  • Can cause pain, burning, or stinging on the skin
  • Not approved for severe eczema
  • No lower-cost generic available

Common Side Effects for Eucrisa

  • Pain, burning, or stinging where the medication is applied (4%)

Warnings for Eucrisa

  • Allergic reactions

Summary for Clobex

Prescription only

Clobetasol is a super potent (very strong) corticosteroid that's applied to the skin. It helps relieve skin inflammation and irritation from moderate-to-severe skin problems, like psoriasis. Clobetasol is available in many different formulations. This includes a cream, ointment, shampoo, topical solution, and foam. Most formulations are for people 12 years and older. But others, like the shampoo and lotion, are for adults only. Some side effects include burning, stinging, and irritation where it's applied. Clobetasol has both brand-name and generic options.

Indications for Clobex

  • Skin rashes and itchy skin - all topical forms except shampoo
  • Plaque psoriasis not on the scalp - all topical forms except shampoo
  • Moderate-to-severe scalp psoriasis - shampoo and certain foams only

Pros and Cons for Clobex

Pros

  • One of the most potent (strongest) topical steroids
  • Applied directly to the affected area(s) of skin
  • Many formulations to choose from, such as ointment, cream, and spray
  • Works well for managing psoriasis symptoms

Cons

  • For short-term use only (usually no more than 2 weeks at a time) to prevent skin thinning and other problems
  • Not safe to use on the face, armpits, or groin
  • Some formulations are only for adults (e.g., shampoo, lotion, spray)
  • Not known if safe to use while pregnant or breastfeeding

Common Side Effects for Clobex

  • Burning
  • Stinging
  • Skin irritation
  • Itching

Warnings for Clobex

  • More skin reactions with longer use and coverings
  • Changes in stress hormone levels
  • Topical steroid withdrawal
  • Higher risk of cataracts and glaucoma
  • Treat any skin infections appropriately
  • Flammable (clobetasol foam, solution, and spray only)

Prices with our coupons for Eucrisa vs. Clobex

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Eucrisa1 tube / 60g of 2%
$158.48$941.56
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Clobetasol1 tube / 60g of 0.05%
$19.32$224.58
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