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Eucrisa vs. Tacrolimus

Eucrisa (crisaborole) is an ointment that's used to treat eczema for people 3 months and older. The medication is a phosphodiesterase 4 (PDE4) inhibitor that works to help reduce skin inflammation and itching from eczema. The ointment is usually applied to the affected area(s) of skin twice a day. The most common side effect is burning or stinging on the skin where you apply the medication.

• Mild-to-moderate eczema

• Pain, burning, or stinging where the medication is applied (4%)

• Allergic reactions

Tacrolimus (Protopic) is a prescription non-steroid ointment used short-term on the skin to treat moderate-to-severe eczema (atopic dermatitis). It's a calcineurin inhibitor that helps lower the immune system’s response so it doesn’t cause inflammation and make eczema worse. Tacrolimus (Protopic) is approved for both adults and children ages 2 years and older who don't have a weakened immune system. It comes as both a brand-name and generic ointment that you apply to the affected area twice daily. Common side effects include stinging, itching, and a burning sensation at the application site.

• Moderate-to-severe eczema in adults and children ages 2 years and older

Adults:

• Skin burning (up to 58%)
• Itchiness (up to 46%)
• Flu-like symptoms (up to 31%)
• Skin redness (up to 28%)
• Headache (up to 20%)

Children:

• Skin burning (up to 43%)
• Itchiness (up to 41%)
• Flu-like symptoms (up to 34%)

• Long-term use and risk of cancer
• Risk of infection
• Swollen lymph nodes
• Sun exposure
• Sudden kidney failure