Key takeaways
Eucrisa (crisaborole) and Elidel (pimecrolimus) are both topical treatments for eczema, but they work differently and have some distinct differences. Eucrisa (crisaborole) is a phosphodiesterase 4 (PDE4) inhibitor that helps reduce inflammation and itching by blocking a protein that controls inflammation in your skin. It is safe for use in children as young as 3 months old and is only available as a brand medication, which can make it expensive. On the other hand, Elidel (pimecrolimus) is a calcineurin inhibitor that works by blocking a protein that activates the immune system, thus reducing inflammation. Elidel (pimecrolimus) is suitable for children 2 years and older and is not recommended for long-term use due to potential risks, including a rare chance of cancer. Unlike Eucrisa, Elidel can be used on the face and neck but should be avoided in people with weakened immune systems. Both medications are applied twice daily and can start showing improvements in about a week.
