Key takeaways
Estring (estradiol) and Estrace (estradiol) are both estrogen replacement therapies used to treat menopausal symptoms, but they have some key differences. Estring is a vaginal ring that releases a steady amount of estrogen over three months, primarily targeting vaginal dryness and burning. Estrace also treats vaginal symptoms due to menopause; however, it is a vaginal cream, initially applied daily and then reduced to a few times a week. Estring is only available as a brand-name medication, while Estrace is available in a lower-cost generic form. Estring is more convenient as it only needs to be replaced every three months, whereas Estrace requires more frequent application. Both treatments carry risks such as blood clots, strokes, and certain cancers; however, the risk may be slightly lower compared to oral estrogen replacement therapies due to their localized application. Additionally, Estring might need to be used with a progestin-based medication if you have a uterus, while Estrace's need for taking a progestin depends on the dosage and duration of use.
