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Daxxify vs. Botox

Daxxify (daxibotulinumtoxinA or daxibotulinumtoxinA-lanm) is an FDA-approved medication for adults to temporarily improve the appearance of frown lines (wrinkles between your eyebrows and in your forehead). It's also used to treat cervical dystonia (muscle spasms in the neck). This medication is injected into the muscles by a trained healthcare provider. Common side effects include headache and pain at the injection site. Daxxify seems to last longer than other botulinum toxin injections (e.g., Botox).

• Temporary improvement in the appearance of moderate-to-severe frown lines (glabellar lines) in adults
• Neck spasms (cervical dystonia) in adults

Frown lines

• Headache (6%)
• Injection site reactions (e.g., pain, redness, swelling; 6%)
• Drooping eyelids (2%)
• Trouble moving parts of the face (1%)

Cervical dystonia

• Headache (7-9%)
• Injection site reactions (e.g., pain, redness; up to 8%)
• Upper respiratory tract infection (up to 5%)
• Muscle weakness (2-5%)
• Muscle and bone pain (4%)
• Trouble swallowing (2-4%)
• Spine pain (2-3%)

• Spread of toxin effects
• Allergic reaction
• Worsening of certain conditions
• Difficulty swallowing or breathing
• Reduced blinking, dry eye, and vision changes (when used for frown lines)

Botox (onabotulinumtoxinA) is a prescription injection used for many medical conditions caused by muscle overactivity or nerve problems. It's FDA approved for treating conditions like overactive bladder, excessive armpit sweating, and for preventing migraines. The medication is injected by a trained healthcare professional. Side effects depend on where the injection is given, but they can include urinary tract infections, headache, and neck pain.

Botox (onabotulinumtoxinA) is different from Botox Cosmetic, which is used for facial and neck lines.

• Overactive bladder (OAB) - adults
• Loss of bladder control caused by nerve-bladder problems - adults
• Nerve-related bladder problem - children 5 years and older
• Headache prevention for chronic migraine - adults
• Muscle spasms - adults and children 2 years and older
• Neck muscle spasms - adults
• Excessive armpit sweating - adults
• Eyelid twitching - adults and children 12 years and older
• Crossed eyes - adults and children 12 years and older

Overactive bladder:

• Urinary tract infection (18%)
• Painful urination (9%)
• Trouble emptying the bladder (6%)

Loss of bladder control:

• Urinary tract infection (24-26%)
• Urine left in the bladder (17%)
• Trouble emptying the bladder (15-17%)
• Difficulty passing urine (15%)

Chronic migraine:

• Neck pain (9%)
• Headache (5%)

Muscle spasms:

• Pain in the arm or leg (up to 9%)
• Muscle weakness (up to 4%)

Neck muscle spasm:

• Trouble swallowing (19%)
• Upper respiratory infection (12%)
• Neck pain (11%)
• Headache (11%)

Excessive armpit sweating:

• Injection site pain (3-10%)
• Bleeding (3-10%)
• Infection (3-10%)

Eyelid twitching:

• Droopy eyelid (21%)
• Damage to surface of the eye (6%)
• Dry eye (6%)

Crossed eyes:

• Droopy eyelid (1-38%)
• Eye misalignment (17%)

• Spread of toxin effect
• Serious allergic reaction
• Difficulty swallowing or breathing
• Lung problems in people with breathing conditions
• Eye problems and bleeding
• Bronchitis and upper respiratory tract infections
• Overactive nervous system
• Urinary tract infections
• Trouble emptying the bladder
• Transmission of diseases