Antifolates are used to treat various types of cancer, including breast cancer, non-small cell lung cancer, and Non-Hodgkin lymphoma. They also have other uses, such as managing rheumatoid arthritis and psoriasis. Antifolates work by slowing down the growth of cancer cells and reducing inflammation in autoimmune disorders. These medications come in different forms, including oral pills, oral liquids, and injections. Examples include methotrexate (Trexall, Rasuvo, Xatmep, Jylamvo, Otrexup) and pemetrexed (Alimta, Pemfexy).