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Otrexup (methotrexate) is a cytotoxic drug that also suppresses the immune system. It is used to treat psoriasis and rheumatoid arthritis. It is slightly more popular than comparable drugs. There are currently no generic alternatives for Otrexup.
GoodRx has partnered with InsideRx and Antares Pharma to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Otrexup is not covered by most Medicare and insurance plans.
With the Patient Assistance Program from HealthWell Foundation, contact the program to see how they can financially help you out.
Otrexup is a specialty medication, which can cost more than standard prescriptions and involve a few extra steps. We'll help you understand what to expect.
| Dosage | Quantity | Retail price | GoodRx price |
|---|
| Dosage | Quantity | Retail price | GoodRx price |
|---|
| 4 injections of 10mg/ 0.4ml | 1 package | $997.23 | $530.40 |
| 4 injections of 12.5mg/ 0.4ml | 1 package | $1,003.99 | $530.40 |
| 4 injections of 15mg/ 0.4ml | 1 package | $1,091.31 | $530.40 |
| 4 injections of 17.5mg/ 0.4ml | 1 package | $995.36 | $530.40 |
| 4 injections of 20mg/ 0.4ml | 1 package | $919.82 | $530.40 |
| 4 injections of 22.5mg/ 0.4ml | 1 package | $938.23 | $530.40 |
| 4 injections of 25mg/ 0.4ml | 1 package | $1,052.48 | $530.40 |
| 10 mg/ 0.4ml | 5 syringes | $1,259.44 | $1,259.44 |
| 12.5mg/ 0.4ml | 4 syringes | $959.92 | $809.44 |
| 15mg/ 0.4ml | 5 syringes | $1,326.02 | $1,009.53 |
| 17.5mg/ 0.4ml | 4 syringes | N/A | $809.44 |
| 20mg/ 0.4ml | 5 syringes | $1,196.53 | $1,009.53 |
| 22.5mg/ 0.4ml | 10 syringes | $2,399.79 | $2,010.01 |
| 25mg/ 0.4ml | 5 syringes | $1,242.34 | $1,009.53 |
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GoodRx coupon prices last updated on 04/16/26.
*Prices subject to change without notice. Sales tax may apply and is not included.
