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Naproxen / Esomeprazole DR Coupon - Naproxen / Esomeprazole DR 500mg/20mg tablet

naproxen / esomeprazole DR

Generic Vimovo
Used for Rheumatoid Arthritis, Osteoarthritis
Used for Rheumatoid Arthritis, Osteoarthritis

Vimovo (naproxen / esomeprazole) is a combination medication for people age 12 years and older who have arthritis. It contains naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that relieves arthritis symptoms like joint pain and swelling. This combination medication also contains the proton pump inhibitor (PPI) esomeprazole to protect against damage to the stomach from naproxen. Vimovo (naproxen / esomeprazole) is a tablet that's taken by mouth twice a day. Side effects can include inflammation of the stomach lining and diarrhea.

Last reviewed on January 2, 2025
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What is Vimovo (naproxen / esomeprazole)?

What is Vimovo (naproxen / esomeprazole) used for?

How Vimovo (naproxen / esomeprazole) works

Vimovo (naproxen / esomeprazole) is a combination of two medications.

  • Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). This pain reliever works by blocking cyclooxygenase (COX), a protein that makes chemicals that cause pain and swelling in the body. By blocking COX, naproxen helps relieve symptoms of arthritis.

  • Esomeprazole is a proton pump inhibitor (PPI). It blocks your body from making stomach acid. Less stomach acid means less irritation to the gut. This protects you from some side effects of naproxen, such as gut irritation, gut damage, and ulcers in the gut.

Are you looking for information on naproxen (Naprosyn) or esomeprazole (Nexium) instead?

Drug Facts

Common BrandsVimovo
Drug ClassNSAID / PPI
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Vimovo (naproxen / esomeprazole)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Inflammation of the stomach lining, leading to symptoms like stomach pain, nausea, and loss of appetite (gastritis, 17%)
  • Diarrhea (6%)

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweat
  • Stroke: sudden weakness on one side of the body; confusion; severe headache; trouble seeing, walking, or speaking
  • Serious bleeding, including stomach bleeding: bleeding or bruising that doesn't stop or go away; blood or coffee ground-like bits in your vomit; bright red, black, or tarry stool
  • Liver damage: yellowing of your skin and whites of your eyes (jaundice), pain in the upper right stomach, itching, nausea, tiredness
  • Kidney damage: change in how often you urinate, blood in your urine, fever, weakness, nausea, loss of appetite.
  • Severe allergic reaction or skin reaction: rash; hives; blisters; peeling; trouble breathing; swelling of the face, tongue, or lips

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Increase in blood pressure
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low magnesium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, tremors
  • Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, trouble concentrating
  • Rash, fever, and swollen lymph nodes
  • Rash on the cheeks or arms that gets worse in the sun
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Round red or dark patches on the skin that may itch, burn, and blister
  • Severe diarrhea, fever
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Vimovo (naproxen / esomeprazole)

thumbs-up

Pros

Works well to relieve pain and swelling from arthritis

Helps protect against stomach irritation and ulcers from naproxen without needing to take another pill

thumbs-down

Cons

Must take twice a day, each time at least 30 minutes before a meal

Has many serious risks from both naproxen and esomeprazole ingredients

Less flexible for dose adjustments since it's a fixed combination of two ingredients

pharmacist-tips

Pharmacist tips for Vimovo (naproxen / esomeprazole)

pharmacist
  • It's recommended to take the lowest dose of Vimovo (naproxen / esomeprazole) possible for the shortest period of time to relieve your arthritis symptoms. This helps lower your risk of the side effects and many safety warnings that come with the medication.

    • Take Vimovo (naproxen / esomeprazole) twice a day, each time at least 30 minutes before eating. If you take it with food, the esomeprazole might not get absorbed as fast and as well into the body. This can make it work less well to protect your stomach from harm caused by the naproxen.

      • Swallow the whole tablet of Vimovo (naproxen / esomeprazole) with water. Don't cut, chew, crush, or dissolve it. The way the tablet works is to release the naproxen for arthritis slowly over several hours. But when the coating gets damaged, too much naproxen can get released too fast. This can raise your risk for side effects.

        • Avoid drinking alcohol while you're taking Vimovo (naproxen / esomeprazole). It can raise your risk of stomach issues.

          • Regularly check your blood pressure at home. Vimovo (naproxen / esomeprazole) can raise your blood pressure. Let your care team know if your blood pressure is consistently higher than normal.

            • Be careful of accidental injuries. You might bleed or bruise more easily after an injury while you're taking Vimovo (naproxen / esomeprazole). Your risk for bleeding is higher if you have any bleeding problems. Also keep in mind that some other medications, like blood thinners and antidepressants, can also raise your risk for bleeding. Get medical help right away if any bleeds don't stop.

              • Tell your care team if you feel tired, lightheaded, or short of breath often. These can be signs of anemia, which is a possible side effect of Vimovo (naproxen / esomeprazole). You might need to get a blood test done to check for anemia.

                • Call your prescriber if you have stomach pain, cramps, or heartburn that doesn't go away while you're taking Vimovo (naproxen / esomeprazole). You might need a check-up to see whether these symptoms are related to a more serious stomach problem.

                  • Tell your prescriber and pharmacist about all prescription medications, over-the-counter products, and herbal supplements you take or plan to take. Your care team can check for harmful drug interactions that can happen with Vimovo (naproxen / esomeprazole). These interactions can block some medications from working well or put you at risk for side effects. Your medications might need dose adjustments or you might need to stop certain medications to lower your risk for harm.

                    faqs

                    Frequently asked questions about Vimovo (naproxen / esomeprazole)

                    Does Vimovo (naproxen / esomeprazole) make you sleepy?
                    Sleepiness wasn't a side effect that people in clinical studies reported while they were taking Vimovo (naproxen / esomeprazole). But keep in mind that everyone can have a different experience with the medication. See how your body reacts to Vimovo (naproxen / esomeprazole) after you take it for the first time. Speak with your prescriber if you feel any concerning sleepiness after you take Vimovo (naproxen / esomeprazole).
                    Does Vimovo (naproxen / esomeprazole) help with back pain?
                    If your back pain is due to ankylosing spondylitis (AS), or arthritis that affects the spine, Vimovo (naproxen / esomeprazole) could be a treatment option for you. This medication is approved for relieving symptoms of different kinds of arthritis, including AS. But if your back pain is from something else, there might be a different option that's more appropriate for you. Speak with your prescriber about treatment options that are right for your specific type of back pain.
                    Is Vimovo (naproxen / esomeprazole) a muscle relaxer?
                    No, Vimovo (naproxen / esomeprazole) isn't a muscle relaxer. As the name suggests, muscle relaxers lessen muscle tightness to relax muscles. They can also help relieve muscle spasms. But Vimovo (naproxen / esomeprazole) is a combination medication that contains the nonsteroidal anti-inflammatory drug (NSAID) called naproxen as the pain reliever. NSAIDs work to lessen pain and swelling.
                    How long does it take for Vimovo (naproxen / esomeprazole) to work?
                    In clinical studies, most people with knee osteoarthritis felt pain relief within a week of taking Vimovo (naproxen / esomeprazole). They also had improvements in other arthritis symptoms like joint stiffness after about 6 weeks of treatment. This symptom relief continued throughout the rest of the 3-month study. Keep in mind that each person can have a different experience with the medication. It could also depend on the type of arthritis you have. Follow up with your prescriber about your arthritis symptoms while you're taking Vimovo (naproxen / esomeprazole).
                    Is Vimovo (naproxen / esomeprazole) over the counter?
                    No, Vimovo (naproxen / esomeprazole) isn't an over-the-counter (OTC) medication. You'll need a prescription for it from a healthcare professional.
                    What's the difference between Vimovo and Duexis?
                    Both Vimovo and Duexis are approved for rheumatoid arthritis (RA) and osteoarthritis (OA). But Vimovo can also be used for people with ankylosing spondylitis (AS) or juvenile idiopathic arthritis (JIA). They're both medications that combine two ingredients in a single pill. They have a nonsteroidal anti-inflammatory drug (NSAID) to help with arthritis pain. The other ingredient helps protect the stomach from damage caused by the NSAID. Vimovo has naproxen for pain relief and esomeprazole to protect the stomach. It's taken twice a day. Duexis has ibuprofen for pain and famotidine to protect the stomach. It's taken three times a day. Compare between the two medications. Speak with your prescriber about which best fits your needs.
                    Can I take naproxen and esomeprazole by themselves instead of Vimovo (naproxen / esomeprazole)?
                    The manufacturer doesn't recommend replacing Vimovo (naproxen / esomeprazole) with separate naproxen and esomeprazole. Vimovo combines both in fixed doses. So you'd need to carefully match the dose of naproxen and esomeprazole to Vimovo. Also with Vimovo, esomeprazole gets absorbed first before naproxen. This gives protection to the stomach lining before naproxen's effect. Regular esomeprazole could take a few days before it provides stomach protection. To get the same benefits, you'd need to carefully plan when to take each medication. And, taking naproxen and esomeprazole separately means taking more pills. Discuss with your prescriber about your options.
                    Can I take other NSAIDs while I'm taking Vimovo (naproxen / esomeprazole)?
                    Don't take other medications that have naproxen or other NSAIDs like ibuprofen with Vimovo (naproxen / esomeprazole) without talking to a healthcare professional first. Vimovo already has naproxen, an NSAID. Taking more than one NSAID at the same time can raise your risk of serious health problems. These risks include heart attack, stroke, stomach bleeding, or kidney damage. Many over-the-counter pain relievers, cold medications, and low-dose aspirin contain NSAIDs. Ask your prescriber or pharmacist if you're not sure whether a product has an NSAID. Ask them whether it's safe with Vimovo (naproxen / esomeprazole).
                    Can I take other heartburn medications while I'm taking Vimovo (naproxen / esomeprazole)?
                    You can take antacids like Tums (calcium carbonate) or Milk of Magnesia (magnesium hydroxide) with Vimovo (naproxen / esomeprazole). But avoid taking extra esomeprazole (Nexium) or similar medications like omeprazole (Prilosec). Vimovo already has esomeprazole. Esomeprazole is a type of heartburn medication called a proton pump inhibitor (PPI). Taking more than one PPI at the same time can raise your risk of side effects, like stomach upset and diarrhea. Ask a healthcare professional if you need help finding a heartburn medication that's safe to take with Vimovo (naproxen / esomeprazole).
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                    What are the risks and warnings for Vimovo (naproxen / esomeprazole)?

                    Vimovo (naproxen / esomeprazole) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Heart attack or stroke

                    • Risk factors: Recent heart attack or stroke | Heart condition | High blood pressure | High cholesterol | Recent heart surgery | Taking a high dose of Vimovo (naproxen / esomeprazole) | Taking Vimovo (naproxen / esomeprazole) for a long time

                      Vimovo (naproxen / esomeprazole) contains an NSAID, which can raise your risk of having a heart attack or stroke. These events can be life-threatening.

                      The risk for heart attack or stroke can appear as early as the first few weeks of taking Vimovo (naproxen / esomeprazole). You're also at higher risk if you take higher doses of the medication. Studies also suggest that the risk of having a heart attack or stroke is higher if you take Vimovo (naproxen / esomeprazole) within the first 2 weeks after heart bypass surgery or after a recent heart attack.

                      To minimize your risk, you'll be prescribed the lowest dose of Vimovo (naproxen / esomeprazole) that relieves your arthritis symptoms for the shortest time possible. Don't take this medication right before or after heart bypass surgery or if you've had a recent heart attack.

                      Call 911 and get medical help right away if you have signs of a heart attack (chest or arm pain, cold sweat, shortness of breath) or stroke (facial drooping, weakness on one side of the body, severe headaches, or sudden changes in your speech or vision).

                      risk-warning

                      Stomach bleeding and ulcers

                      • Risk factors: History of stomach ulcers or stomach bleeding | Bleeding problems | Advanced liver problems | Taking Vimovo (naproxen / esomeprazole) for a long time | Taking other medications that can raise the risk of bleeding | Taking more than one NSAID medication | Taking low-dose aspiring | Smoking | Drinking alcohol | Age 65 years or older | Poor health

                        The naproxen component of Vimovo can cause dangerous bleeding, ulcers, and tearing in the stomach, intestines, or esophagus (the tube connecting your mouth to your stomach). The other component of Vimovo, esomeprazole, is meant to help lower the risk for this damage to the digestive tract. But it's still important to be aware that it can happen at any time without warning symptoms even while you're taking this medication.

                        Stop taking Vimovo (naproxen / esomeprazole) and go to the emergency room right away if you have any signs of serious stomach bleeding. This includes bloody vomit; vomit that looks like coffee ground-like bits; or bright red, black, or tarry stool.

                        risk-warning

                        Liver damage

                        Some people who take NSAIDs like the naproxen component in Vimovo had elevated liver enzyme levels on their blood test results. This can be a sign of liver damage. Although rare, liver damage could be severe.

                        Let your prescriber know if you have liver problems before you start taking Vimovo (naproxen / esomeprazole) to check that it's safe for you to take. People who have severe liver problems should avoid taking this medication.

                        Watch for symptoms of liver damage, such as yellowing of your skin or whites of your eyes (jaundice), nausea, diarrhea, tiredness, pain in the upper right stomach, and flu-like symptoms. Let your provider know if you notice any of these symptoms while you're taking Vimovo (naproxen / esomeprazole). You might need to stop taking the medication while your care team checks out the problem.

                        risk-warning

                        High blood pressure, heart failure, and fluid buildup in the body

                        • Risk factors: History of high blood pressure or heart failure

                          Taking Vimovo (naproxen / esomeprazole) can lead to new or worsening high blood pressure. The medication can also cause your body to hold onto fluids, which can look like swelling in the feet, ankles, hands, or belly. Fluid buildup in the body can add to the rise in blood pressure. It can also worsen heart failure for people with this heart condition.

                          Tell your prescriber about your medical history before you start Vimovo (naproxen / esomeprazole), especially if you have high blood pressure or heart failure. Your prescriber can weigh the risks and benefits of treatment. This medication isn't recommended if you have severe heart failure. In addition, Vimovo (naproxen / esomeprazole) can make certain heart medications used for blood pressure, heart failure, and fluid buildup work less well.

                          It's important to regularly check your blood pressure while you're taking Vimovo (naproxen / esomeprazole). Let your prescriber know if your blood pressure is consistently higher than usual or if your symptoms of heart failure get worse.

                          risk-warning

                          Kidney damage

                          • Risk factors: Kidney problems | Liver problems | Heart failure | Dehydration | Age 65 years and older | Taking certain blood pressure medications (e.g., water pills, ACE inhibitors, ARBs) | Taking Vimovo (naproxen / esomeprazole) for a long time

                            Vimovo (naproxen / esomeprazole) can cause kidney damage that can happen at any time. Discuss with your prescriber about whether this medication is safe for you if you have kidney problems. People at risk for kidney problems who take Vimovo (naproxen / esomeprazole) might need blood tests during treatment so the care team can keep an eye on kidney health.

                            Stop taking Vimovo (naproxen / esomeprazole) and let your care team know if you have a change in how often you urinate, blood in your urine, fever, weakness, nausea, or a loss of appetite. These can be signs of kidney damage.

                            risk-warning

                            Severe allergic reaction or skin reaction

                            • Risk factors: Allergy to naproxen | Asthma related to NSAID use

                              Vimovo (naproxen / esomeprazole) can cause serious and sometimes life-threatening allergic reactions, such as anaphylaxis or drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. It can also cause severe skin reactions, like Stevens-Johnson syndrome (SJS).

                              Stop taking Vimovo (naproxen / esomeprazole) and get medical help right away if you notice any unusual and concerning changes to your skin, including rash, hives peeling, or blistering. Look out for any fever or swollen lymph nodes because they can happen with the allergic reaction. Call 911 right away if you have trouble breathing or swelling in the face.

                              risk-warning

                              Abnormal nutrient and electrolyte levels

                              • Risk factors: Taking Vimovo (naproxen / esomeprazole) for a long time | Kidney damage | Medical conditions that cause abnormal electrolyte levels | Taking medications that can raise potassium levels | Taking medications that can lower vitamin B12 or magnesium levels

                                Vimovo (naproxen / esomeprazole) might raise your potassium levels. The risk is higher if you have kidney damage (which could also be caused by the medication). In addition, taking PPIs like the esomeprazole in Vimovo for a long time can rarely cause low magnesium levels and low vitamin B12 levels. Magnesium levels typically drop after taking the medication for at least 3 months, though in most cases after a year of treatment. And vitamin B12 levels usually start to go down after more than 3 years of treatment.

                                Depending on your risk factors, you might need to get blood work done before you start Vimovo (naproxen / esomeprazole) and periodically during treatment. This helps your prescriber check that your nutrient and electrolyte levels are in a safe range.

                                Contact your care team if you have any symptoms of abnormal nutrient or electrolyte levels. These can include tiredness, lightheadedness, weakness, muscle cramps, nausea, tinging or numbness, and pale skin. More serious symptoms are trouble breathing and an irregular heartbeat. You might need supplementation as treatment. If supplementation isn't enough, you might need to stop taking Vimovo (naproxen / esomeprazole).

                                risk-warning

                                Bone fracture

                                • Risk factors: History of osteoporosis | Taking Vimovo (naproxen / esomeprazole) for a year or longer | Taking high doses of esomeprazole

                                  Some studies suggest that PPIs (like the esomeprazole component of Vimovo) can raise the risk for fractures at the hip, wrist, or spine. These fractures might be related to bone weakening or osteoporosis. They might be more likely to happen if you take Vimovo (naproxen / esomeprazole) for longer than 1 year.

                                  Vimovo (naproxen / esomeprazole) has a set dose of esomeprazole (40 mg per day). Discuss with your prescriber about whether this medication is safe for you if you have or are at risk of osteoporosis. Your prescriber might decide on a different medication that provides a lower dose of a PPI to lessen your risk for fracture.

                                  risk-warning

                                  Lupus

                                  Some people who took PPIs like the esomeprazole in Vimovo developed new or worsening lupus, which is an autoimmune condition. This can happen within days to years of treatment. Symptoms can include rash (e.g., butterfly rash across cheeks and nose), joint pain, tiredness, and on-and-off fever. Stop taking Vimovo (naproxen / esomeprazole) and contact your care team if you notice any symptoms of lupus while you're taking this medication. Most times, symptoms improve within a few months after stopping the medication.

                                  risk-warning

                                  Harm to unborn baby

                                  • Risk factors: Currently pregnant

                                    Speak with your prescriber about whether it's safe for you to take Vimovo (naproxen / esomeprazole) if you're pregnant. This medication isn't recommended for people who are 20 weeks pregnant or are at a later stage in pregnancy.

                                    This combination medication contains naproxen, which can cause problems with how the unborn baby's kidneys and heart develop if taken during the second half of pregnancy. Taking naproxen after 20 weeks of pregnancy can also cause complications that affect how other organs develop.

                                    dosage

                                    Vimovo (naproxen / esomeprazole) dosage forms

                                    The average cost for 60 tablets of 500mg/20mg of Vimovo (naproxen / esomeprazole) is $197.18 with a free GoodRx coupon. This is 91.57% off the average retail price of $2340.00.
                                    tablet
                                    Tablet
                                    DosageQuantityPrice as low asPrice per unit
                                    375mg/20mg60 tablets$171.47$2.86
                                    500mg/20mg60 tablets$197.18$3.29

                                    Typical dosing for Vimovo (naproxen / esomeprazole)

                                    • People 12 years and older weighing more than 110 lbs: The typical dose is 375 mg/20 mg (naproxen/esomeprazole) by mouth twice a day. If needed, your prescriber can raise the dose to 500 mg/20 mg (naproxen/esomeprazole) twice a day. Take the medication at least 30 minutes before eating.

                                    • People 12 years and older weighing between 84 lbs and 110 lbs: The typical dose is 375 mg/20 mg (naproxen/esomeprazole) by mouth twice a day. Take the medication at least 30 minutes before meals.

                                    • Children below the age of 12 or weighing less than 84 lbs: Ask your child's pediatrician to see what other options there are.

                                    The two strengths of Vimovo (naproxen / esomeprazole) available both provide a total daily dose of 40 mg of esomeprazole. If this is too much esomeprazole for you, ask your prescriber about other options that might be more appropriate for you.

                                    drug-cost

                                    How much does Vimovo (naproxen / esomeprazole) cost?

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                                    contraindications-icon

                                    Vimovo (naproxen / esomeprazole) contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vimovo (naproxen / esomeprazole) will not be safe for you to take.
                                    alternatives

                                    What are alternatives to Vimovo (naproxen / esomeprazole)?

                                    There are a number of medications that your doctor can prescribe in place of Vimovo (naproxen / esomeprazole). Compare a few possible alternatives below.
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                                    Vimovo (naproxen / esomeprazole) images

                                    Yellow Oval Ne 500 - Naproxen / Esomeprazole Magnesium 500mg-20mg Delayed-Release Tablet
                                    This medicine is Yellow, Oval Tablet Imprinted With "Ne 500".Yellow Oval Ne 500 - Naproxen / Esomeprazole Magnesium 500mg-20mg Delayed-Release Tablet

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                                    References

                                    Best studies we found
                                    View All References (2)

                                    National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Symptoms & causes of gastritis & gastropathy.

                                    U.S. Food and Drug Administration. (2022). FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid.

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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