Key takeaways
Vimovo (naproxen/esomeprazole) and Aleve (naproxen sodium) are both medications used to treat pain and inflammation, particularly for conditions like arthritis. They both contain nonsteroidal anti-inflammatory drugs (NSAID). However, Vimovo is a combination medication that also contains esomeprazole, a proton pump inhibitor (PPI), to help protect the stomach from ulcers caused by naproxen. Aleve, on the other hand, is available over-the-counter and only contains naproxen sodium. Vimovo is taken twice a day, while Aleve is typically taken every 8 to 12 hours. Vimovo requires a prescription, whereas Aleve can be purchased over-the-counter. Common side effects of both medications include an upset stomach and nausea. Both medications can also increase the risk of serious side effects like heart attack, stroke, and stomach bleeding, especially if taken with other NSAIDs or blood thinners.
