Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Vimovo vs. Aleve

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Vimovo (naproxen / esomeprazole)
    Naproxen sodium (Aleve)
  • Vimovo (naproxen / esomeprazole)
    Naproxen sodium (Aleve)

  • Summary of Vimovo vs. Aleve

    Summary for NSAID / PPI
    Prescription only

    Vimovo (naproxen / esomeprazole) is a combination medication for people age 12 years and older who have arthritis. It contains naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that relieves arthritis symptoms like joint pain and swelling. This combination medication also contains the proton pump inhibitor (PPI) esomeprazole to protect against damage to the stomach from naproxen. Vimovo (naproxen / esomeprazole) is a tablet that's taken by mouth twice a day. Side effects can include inflammation of the stomach lining and diarrhea.

    Summary for NSAID
    Prescription only

    Over-the-counter naproxen sodium (Aleve) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children ages 12 years and older to ease minor aches and pains, and to relieve fever. Naproxen sodium (Aleve) works by blocking certain proteins in the body that cause inflammation and pain. Naproxen sodium (Aleve) is taken by mouth, typically every 6 to 8 hours. Common side effects of this medication include stomach upset, dizziness, headache. It's best to avoid drinking alcohol while taking naproxen sodium (Aleve) because doing so can worsen gut-related side effects.

  • Indications of Vimovo vs. Aleve

    Indications for
    •Treatment of different kinds of arthritis while lowering the risk for stomach ulcers
    •Osteoarthritis (OA) in adults
    •Rheumatoid arthritis (RA) in adults
    •Ankylosing spondylitis (AS) in adults
    •Arthritis in children 12 years and older (juvenile idiopathic arthritis, JIA)
    Indications for
    •Short-term relief of minor aches and pains due:
    •Headaches
    •Arthritis
    •Muscle aches
    •Backache
    •Menstrual cramps
    •Common cold
    •Lower fever

  • Pros and Cons of Vimovo vs. Aleve

    Pros and Const for NSAID / PPI
    Pros
    •Works well to relieve pain and swelling from arthritis
    •Helps protect against stomach irritation and ulcers from naproxen without needing to take another pill
    Cons
    •Must take twice a day, each time at least 30 minutes before a meal
    •Has many serious risks from both naproxen and esomeprazole ingredients
    •Less flexible for dose adjustments since it's a fixed combination of two ingredients
    Pros and Const for NSAID
    Pros
    •Works well for treating pain and inflammation
    •Available over the counter (OTC) and as a lower-cost generic
    •Effects last longer than other NSAIDs, such as ibuprofen (Advil)
    Cons
    •OTC naproxen is only available as a tablet
    •Can raise your risk for bleeding
    •Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

  • Common Side Effects of Vimovo vs. Aleve

    Common Side Effects for
    •Inflammation of the stomach lining, leading to symptoms like stomach pain, nausea, and loss of appetite (gastritis, 17%)
    •Diarrhea (6%)
    Common Side Effects for
    •Heartburn
    •Nausea
    •Stomach pain
    •Dizziness
    •Headache

  • Warnings of Vimovo vs. Aleve

    Common Side Effects for
    •Heart attack or stroke
    •Stomach bleeding and ulcers
    •Liver damage
    •High blood pressure, heart failure, and fluid buildup in the body
    •Kidney damage
    •Severe allergic reaction or skin reaction
    •Abnormal nutrient and electrolyte levels
    •Bone fracture
    •Lupus
    •Harm to unborn baby
    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions
    •Not for use while pregnant or breastfeeding

  • Prices with our coupons for Vimovo vs. Aleve

    Learn more about Vimovo
    Learn more about Naproxen sodium

Compare other Rheumatoid Arthritis and Osteoarthritis drugs

Arthrotec vs VimovoDuexis vs VimovoVimovo vs AleveVimovo vs CelebrexVimovo vs NaproxenAleve vs TylenolArthrotec vs IbuprofenArthrotec vs MobicArthrotec vs NaprosynArthrotec vs VoltarenAspirin vs NaproxenCelebrex vs MobicCelebrex vs MotrinCelebrex vs NaproxenDuexis vs IbuprofenDuexis vs MobicDuexis vs NaprosynDuexis vs VoltarenIbuprofen vs CelebrexIndocin vs CelebrexLodine vs ArthrotecLodine vs CelebrexMeloxicam vs AleveMeloxicam vs CelebrexNaproxen vs ArthrotecRelafen vs ArthrotecRelafen vs CelebrexTylenol vs ArthrotecTylenol vs CelebrexVoltaren Gel vs Celebrex
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.