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Vimovo vs. Duexis

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Vimovo

(naproxen / esomeprazole)

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Duexis

(ibuprofen / famotidine)

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Summary for Vimovo

Prescription only

Vimovo (naproxen / esomeprazole) is a combination medication for people age 12 years and older who have arthritis. It contains naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that relieves arthritis symptoms like joint pain and swelling. This combination medication also contains the proton pump inhibitor (PPI) esomeprazole to protect against damage to the stomach from naproxen. Vimovo (naproxen / esomeprazole) is a tablet that's taken by mouth twice a day. Side effects can include inflammation of the stomach lining and diarrhea.

Indications for Vimovo

Pros and Cons for Vimovo

Pros

  • Works well to relieve pain and swelling from arthritis
  • Helps protect against stomach irritation and ulcers from naproxen without needing to take another pill

Cons

  • Must take twice a day, each time at least 30 minutes before a meal
  • Has many serious risks from both naproxen and esomeprazole ingredients
  • Less flexible for dose adjustments since it's a fixed combination of two ingredients

Common Side Effects for Vimovo

  • Inflammation of the stomach lining, leading to symptoms like stomach pain, nausea, and loss of appetite (gastritis, 17%)
  • Diarrhea (6%)

Warnings for Vimovo

  • Heart attack or stroke
  • Stomach bleeding and ulcers
  • Liver damage
  • High blood pressure, heart failure, and fluid buildup in the body
  • Kidney damage
  • Severe allergic reaction or skin reaction
  • Abnormal nutrient and electrolyte levels
  • Bone fracture
  • Lupus
  • Harm to unborn baby

Summary for Duexis

Prescription only

Duexis is a prescription medication that contains ibuprofen (a non-steroidal anti-inflammatory drug (NSAID)) and famotidine (a H2 blocker). It's taken by adults to treat osteoarthritis (OA) and rheumatoid arthritis (RA), while also helps protect against stomach ulcer. This medication is taken by mouth three times per day. Side effects include headache, nausea, and high blood pressure. Brand name Duexis has been discontinued; this medication is only available as a generic.

Indications for Duexis

Pros and Cons for Duexis

Pros

Cons

  • Taken 3 times a day
  • Can't be crushed and doesn't come as a liquid; not a good choice for people who can't swallow tablets
  • Not safe for people with certain medical conditions, such as heart problems or kidney problems

Common Side Effects for Duexis

Warnings for Duexis

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure, heart failure, and swelling
  • Kidney damage and high potassium levels
  • Liver problems
  • Severe allergic reactions
  • Harm to unborn babies
  • Accidentally taking too much medication
  • Changes in vision

Prices with our coupons for Vimovo vs. Duexis

Price Card Drug Icon
Naproxen/Esomeprazole DR60 tablets / 500mg/20mg
$128.03$2,289.03
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Price Card Drug Icon
Ibuprofen/Famotidine90 tablets / 800mg/26.6mg
$68.72$858.83
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