Medications for canker sores are used to treat mouth ulcers and relieve pain from minor oral irritation. These medications also have other uses, such as treating sore throats. They work by numbing the affected area or cauterizing sores to promote healing. Common classes include topical anesthetics and debriding agents. Topical anesthetics like benzocaine / menthol (Cepacol) are usually available as lozenges or gels. Debriding agents, such as sulfonated phenolics / sulfuric acid, are typically applied directly to the sore.