Zinbryta vs. Lemtrada for Multiple Sclerosis: Important Differences and Potential Risks.

Key takeaways

Zinbryta (daclizumab) and Lemtrada (alemtuzumab) are both used to treat relapsing forms of multiple sclerosis (MS) in adults, but they have notable differences. Zinbryta is a monoclonal antibody that helped lower inflammationin the brain. However, it was discontinued in the United States due to safety concerns, including liver injury and immune-related problems. In contrast, Lemtrada, an anti-CD52 monoclonal antibody, is still available but only for those who haven't responded well to at least two other MS medications. Lemtrada is administered as an annual IV infusion, after the first treatment course. It has a high risk of serious side effects, such as developing autoimmune problems, infections, and cancer, and is only available through a special REMS program.

Zinbryta

(daclizumab)

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Lemtrada

(alemtuzumab)

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Summary for Zinbryta

Discontinued

Zinbryta (daclizumab) is a medication used to treat relapsing forms of multiple sclerosis (MS) in adults. It's no longer available in the United States, because it was discontinued.

Indications for Zinbryta

Relapsing forms of multiple sclerosis (MS)

Pros and Cons for Zinbryta

Pros

Cons

Summary for Lemtrada

Prescription only

Lemtrada (alemtuzumab) is an anti-CD52 monoclonal antibody. It's used to treat relapsing forms of multiple sclerosis (MS) in adults, but only when other MS medications haven't worked well. Lemtrada (alemtuzumab) is given as an infusion through the veins once per year by a healthcare provider. Since this medication has many risks and side effects, it's only available through a Risk Evaluation and Mitigation Strategy (REMS) program) called the Lemtrada REMS program. Some common side effects of Lemtrada (alemtuzumab) include rash, headache, and fever.

Indications for Lemtrada

Relapsing forms of multiple sclerosis (MS) in adults who haven't responded well enough to at least two other MS medications

Pros and Cons for Lemtrada

Pros

Works well to treat relapsing forms of MS
Treatment courses are short and are only once per year
Not many known interactions with other medications

Cons

A lot of potential risks and side effects, including serious allergic reaction, blood problems, and liver problems
Each treatment will take a least 6 hours at the clinic because of pre-treatment, infusion time, and monitoring time
Needs to be given as an IV injection by a healthcare professional