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Xeomin vs. Botox Cosmetic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Xeomin (incobotulinumtoxinA) and Botox Cosmetic (onabotulinumtoxinA) are both neuromuscular blockers used to treat frown lines, but they have some differences. Both medications are injected by a healthcare professional and work by stopping a chemical called acetylcholine, which helps relax muscles. Xeomin is FDA-approved for treating various conditions, including excessive drooling, arm and neck spasms, and eye twitching, as well as frown lines, while Botox Cosmetic is specifically approved for improving the appearance of frown lines, forehead lines, and crow's feet lines. Xeomin is used for both medical and cosmetic purposes, whereas Botox Cosmetic is only for cosmetic use, though other Botox products have additional medical uses. Xeomin's effects can be seen within 7 days and last 3 to 4 months, while Botox Cosmetic starts working in 1 to 2 days and can last up to 4 months. Common side effects of Xeomin include dry mouth, diarrhea, and muscle weakness, while Botox Cosmetic may cause drooping eyelids and headaches. Both medications have risks of spreading toxin effects, which can lead to serious side effects like trouble breathing or swallowing. Neither medication is available in a generic form, and both require repeat injections as their effects are not permanent.

Xeomin

(incobotulinumtoxinA)

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Botox Cosmetic

(onabotulinumtoxinA)

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Summary for Xeomin

Prescription only

Xeomin (incobotulinumtoxinA) is an injectable medication used to treat many movement problems, drooling, and frown lines, but it can have dangerous side effects if it spreads to areas outside of the injection. It's typically administered by a healthcare provider.

Indications for Xeomin

  • Long-term excessive drooling (sialorrhea) in people 2 years and older
  • Arm spasms in people 2 years and older
  • Uncontrollable neck spasms (cervical dystonia) in adults
  • Uncontrollable eye twitching (blepharospasm) in adults
  • Frown lines in adults

Pros and Cons for Xeomin

Pros

  • Works well to treat many different movement problems and frown lines
  • Injected directly into the affected muscles
  • Can see improvement in your condition within 7 days
  • Effects typically last 3 to 4 months after each treatment

Cons

  • Needs to be injected by a healthcare provider
  • Injections can be uncomfortable
  • Requires repeat injections since effects wear off over time
  • Has a risk of swallowing, speaking, or breathing problems
  • Brand only, so might be expensive

Common Side Effects for Xeomin

Excessive drooling:

  • Need for tooth removal (5% in adults)
  • Dry mouth (4% in adults)
  • Diarrhea (4% in adults)
  • High blood pressure (4% in adults)
  • Fall (3% in adults)
  • Bronchitis (3% in adults, 1% in children)
  • Trouble speaking (3% in adults)
  • Back pain (3% in adults)
  • Dry eye (3% in adults)

Arm spasms:

  • Seizure (3% in adults)
  • Nose and throat infection (2% in adults, 3-6% in children)
  • Bronchitis (2-3% in children)

Neck spasms:

  • Trouble swallowing (13-18%)
  • Nervous system problems (16-17%)
  • Neck pain (7-15%)
  • Infections (13-14%)
  • Breathing problems (10-13%)
  • Muscle weakness (7-11%)
  • Pain at injection site (4-9%)
  • Muscle or bone pain (4-7%)

Eye twitching:

  • Drooping eyelid (19%)
  • Dry eye (16%)
  • Dry mouth (16%)
  • Vision changes (e.g., blurred vision, 12%)
  • Injection site reaction (11%)
  • Diarrhea (8%)
  • Headache (7%)
  • Nose and throat infection (5%)
  • Respiratory tract infection (5%)
  • Shortness of breath (5%)

Frown lines:

  • Headache (5%)

Warnings for Xeomin

  • Spread of toxin effects
  • Difficulty swallowing or breathing
  • Eye problems due to reduced blinking
  • Worsening of glaucoma
  • Drooping eyelids

Summary for Botox Cosmetic

Prescription only

Botox Cosmetic (onabotulinumtoxinA) is a prescription injection used in adults to temporarily improve the look of facial lines. It's FDA approved to treat moderate to severe frown lines between the eyebrows, forehead lines, crow’s feet, and neck lines. The medication is injected directly into the facial muscles by a trained healthcare professional. Side effects can vary depending on the injection site and can include headache and droopy eyelids.

Botox Cosmetic (onabotulinumtoxinA) is different from medical Botox, which is used for certain health conditions like migraines or muscle spasms.

Indications for Botox Cosmetic

Temporarily improves the appearance of moderate to severe facial lines, including:

  • Frown lines
  • Crow's feet
  • Forehead lines
  • Neck lines

Pros and Cons for Botox Cosmetic

Pros

  • Can treat many facial and neck lines at the same time
  • Might start to see results within days
  • Lasts up to 3 to 4 months
  • Quick recovery time after injections

Cons

  • Needs to be injected by a trained healthcare professional
  • Injections can be uncomfortable
  • Not permanent, requires repeat injections
  • Side effects include droopy eyelids and headache

Common Side Effects for Botox Cosmetic

Frown lines:

  • Droopy eyelids (3%)

Crow's feet:

  • Eyelid swelling (1%)

Forehead lines:

  • Headache (9%)

Warnings for Botox Cosmetic

  • Spread of toxin effect
  • Serious allergic reaction
  • Heart-related side effects
  • Difficulty swallowing or breathing
  • Eye and vision problems
  • Transmission of diseases

Prices with our coupons for Xeomin vs. Botox Cosmetic

Price Card Drug Icon
Xeomin1 vial / 100 units
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Botox Cosmetic1 vial / 50 units
$363.61$459.24
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