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Velsipity vs. Zeposia

Velsipity (etrasimod) is a medication that treats ulcerative colitis (UC) in adults. It works as a sphingosine 1-phosphate (S1P) receptor modulator to help relieve gut inflammation and symptoms of UC. The usual dose is 1 tablet by mouth once a day. Velsipity (etrasimod) can cause side effects like headache and dizziness. It also has a few serious risks, including infection, heart problems, and liver damage. Velsipity (etrasimod) is available as a brand-name medication.

• Moderate-to-severe ulcerative colitis (UC) in adults

• Headache (9%)
• Higher liver enzyme levels (6%)
• Dizziness (5%)

• Risk of infections
• Slow heart rhythm and heart rate
• High blood pressure
• Liver problems
• Eye problem (macular edema)
• Harm to an unborn baby
• Possible risk of skin cancer
• Brain problems
• Breathing problems

Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.

• Relapsing forms of multiple sclerosis (MS) in adults
• Moderate-to-severe ulcerative colitis (UC) in adults

• Upper respiratory infection (26%)
• High liver enzyme levels (10%)

• Risk of infections
• Risk of brain infection (progressive multifocal leukoencephalopathy)
• Slow heart rate and heart rhythm
• Higher blood pressure
• Liver damage
• Breathing problems
• Eye problem called macular edema
• Brain problem called posterior reversible encephalopathy syndrome (PRES)
• Possible risk of skin cancer
• Harm to an unborn baby