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Trulicity vs. Metformin

Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

• Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
• Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors

• Nausea (12-21%)
• Diarrhea (7-13%)
• Vomiting (6-13%)
• Stomach pain (7-9%)
• Low appetite (5-9%)
• Fatigue (4-6%)
• Indigestion (3-6%)

• Thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Low blood sugar when used with certain diabetes medications
• Severe allergic reactions
• Kidney damage
• Severe stomach-related side effects
• Worsening eye problems in people with diabetic retinopathy
• Gallbladder problems
• Breathing fluid into your lungs during anesthesia or deep sedation

Immediate-release metformin is an oral diabetes medication. It's approved for people 10 years of age and older with Type 2 diabetes. The medication belongs to the drug class called biguanides. It works best to lower blood sugar levels with a diabetes-friendly diet and exercise plan. Immediate-release metformin comes as a tablet and an oral solution. You take this medication by mouth usually two to three times a day. It's recommended to take each dosage with food to help lessen side effects like diarrhea and nausea.

• Type 2 diabetes in people ages 10 years and older

• Diarrhea (53%)
• Nausea or vomiting (26%)
• Gas (12%)
• Weakness (9%)

• Lactic acidosis
• Low vitamin B12 levels
• Low blood sugar (hypoglycemia) when taken with certain other diabetes medications