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Stelara vs. Cosentyx

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

• Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
• Psoriatic arthritis (PsA) - adults and children 6 years and older
• Moderate-to-severe Crohn's disease (CD) - adults only
• Moderate-to-severe ulcerative colitis (UC) - adults only

Plaque psoriasis

• Common cold symptoms (7-8%)
• Upper respiratory tract infection (4-5%)
• Headache (5%)

Psoriatic arthritis

• Joint pain (3%)
• Nausea (3%)

Crohn's disease

• Common cold symptoms (11%)
• Redness at the injection site (5%)
• Yeast infection (5%)
• Bronchitis (5%)

Ulcerative colitis:

• Common cold symptoms (24%)
• Headache (10%)
• Stomach pain (7%)
• Flu infection (6%)
• Fever (5%)

• Infections
• Cancers
• Severe allergic reaction
• Brain condition
• Vaccines
• Lung problems

Cosentyx (secukinumab) is an injectable medication that treats many inflammatory conditions. This includes plaque psoriasis (PsO), psoriatic arthritis (PsA), and hidradenitis suppurativa (HS), among others. It works as an interleukin 17 antagonist to lower inflammation in the body. Some people might need a few starter doses. But it's usually injected under the skin once a month. You can use the prefilled syringes, Sensoready Pens, or UnoReady Pens to inject. For some conditions, the medication can also be given as an infusion into the vein at a clinic. The dosing depends on your age, health condition, and treatment plan. Side effects include upper respiratory tract infections and upset stomach.

• Moderate-to-severe plaque psoriasis (PsO) in people 6 years and older
• Psoriatic arthritis (PsA) in people 2 years and older
• Ankylosing spondylitis (AS) in people 12 years and older
• Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
• Moderate-to-severe hidradenitis suppurativa (HS) in people 12 years and older
• Enthesitis-related arthritis in children 4 years and older

• Common cold (11%)
• Diarrhea (4%)
• Upper respiratory tract infections (3%)

• Risk of infection
• Caution when getting vaccines
• Eczema-like skin reaction
• Allergic reaction
• Inflammatory bowel disease